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Immigrant IBD Patients in Spain Are Younger, Have More Extraintestinal Manifestations and Use More Biologics Than Native Patients

BACKGROUND: Previous studies comparing immigrant ethnic groups and native patients with IBD have yielded clinical and phenotypic differences. To date, no study has focused on the immigrant IBD population in Spain. METHODS: Prospective, observational, multicenter study comparing cohorts of IBD patien...

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Autores principales: Gutiérrez, Ana, Zapater, Pedro, Ricart, Elena, González-Vivó, María, Gordillo, Jordi, Olivares, David, Vera, Isabel, Mañosa, Míriam, Gisbert, Javier P., Aguas, Mariam, Sánchez-Rodríguez, Eugenia, Bosca-Watts, Maia, Laredo, Viviana, Camps, Blau, Marín-Jiménez, Ignacio, Zabana, Yamile, Martín-Arranz, María Dolores, Muñoz, Roser, Navarro, Mercè, Sierra, Eva, Madero, Lucía, Vela, Milagros, Pérez-Calle, José Lázaro, Sainz, Empar, Calvet, Xavier, Arias, Lara, Morales, Victor, Bermejo, Fernando, Fernández-Salazar, Luis, Van Domselaar, Manuel, De Castro, Luisa, Rodríguez, Cristina, Muñoz-Villafranca, Carmen, Lorente, Rufo, Rivero, Montserrat, Iglesias, Eva, Herreros, Belén, Busquets, David, Riera, Joan, Martínez-Montiel, María Pilar, Roldón, Marta, Roncero, Oscar, Hinojosa, Esther, Sierra, Mónica, Barrio, Jesús, De Francisco, Ruth, Huguet, José, Merino, Olga, Carpio, Daniel, Ginard, Daniel, Muñoz, Fernando, Piqueras, Marta, Almela, Pedro, Argüelles-Arias, Federico, Alcaín, Guillermo, Bujanda, Luis, Manceñido, Noemí, Lucendo, Alfredo J., Varela, Pilar, Rodríguez-Lago, Iago, Ramos, Laura, Sempere, Laura, Sesé, Eva, Barreiro-de Acosta, Manuel, Domènech, Eugeni, Francés, Rubén
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844561/
https://www.ncbi.nlm.nih.gov/pubmed/35178413
http://dx.doi.org/10.3389/fmed.2022.823900
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author Gutiérrez, Ana
Zapater, Pedro
Ricart, Elena
González-Vivó, María
Gordillo, Jordi
Olivares, David
Vera, Isabel
Mañosa, Míriam
Gisbert, Javier P.
Aguas, Mariam
Sánchez-Rodríguez, Eugenia
Bosca-Watts, Maia
Laredo, Viviana
Camps, Blau
Marín-Jiménez, Ignacio
Zabana, Yamile
Martín-Arranz, María Dolores
Muñoz, Roser
Navarro, Mercè
Sierra, Eva
Madero, Lucía
Vela, Milagros
Pérez-Calle, José Lázaro
Sainz, Empar
Calvet, Xavier
Arias, Lara
Morales, Victor
Bermejo, Fernando
Fernández-Salazar, Luis
Van Domselaar, Manuel
De Castro, Luisa
Rodríguez, Cristina
Muñoz-Villafranca, Carmen
Lorente, Rufo
Rivero, Montserrat
Iglesias, Eva
Herreros, Belén
Busquets, David
Riera, Joan
Martínez-Montiel, María Pilar
Roldón, Marta
Roncero, Oscar
Hinojosa, Esther
Sierra, Mónica
Barrio, Jesús
De Francisco, Ruth
Huguet, José
Merino, Olga
Carpio, Daniel
Ginard, Daniel
Muñoz, Fernando
Piqueras, Marta
Almela, Pedro
Argüelles-Arias, Federico
Alcaín, Guillermo
Bujanda, Luis
Manceñido, Noemí
Lucendo, Alfredo J.
Varela, Pilar
Rodríguez-Lago, Iago
Ramos, Laura
Sempere, Laura
Sesé, Eva
Barreiro-de Acosta, Manuel
Domènech, Eugeni
Francés, Rubén
author_facet Gutiérrez, Ana
Zapater, Pedro
Ricart, Elena
González-Vivó, María
Gordillo, Jordi
Olivares, David
Vera, Isabel
Mañosa, Míriam
Gisbert, Javier P.
Aguas, Mariam
Sánchez-Rodríguez, Eugenia
Bosca-Watts, Maia
Laredo, Viviana
Camps, Blau
Marín-Jiménez, Ignacio
Zabana, Yamile
Martín-Arranz, María Dolores
Muñoz, Roser
Navarro, Mercè
Sierra, Eva
Madero, Lucía
Vela, Milagros
Pérez-Calle, José Lázaro
Sainz, Empar
Calvet, Xavier
Arias, Lara
Morales, Victor
Bermejo, Fernando
Fernández-Salazar, Luis
Van Domselaar, Manuel
De Castro, Luisa
Rodríguez, Cristina
Muñoz-Villafranca, Carmen
Lorente, Rufo
Rivero, Montserrat
Iglesias, Eva
Herreros, Belén
Busquets, David
Riera, Joan
Martínez-Montiel, María Pilar
Roldón, Marta
Roncero, Oscar
Hinojosa, Esther
Sierra, Mónica
Barrio, Jesús
De Francisco, Ruth
Huguet, José
Merino, Olga
Carpio, Daniel
Ginard, Daniel
Muñoz, Fernando
Piqueras, Marta
Almela, Pedro
Argüelles-Arias, Federico
Alcaín, Guillermo
Bujanda, Luis
Manceñido, Noemí
Lucendo, Alfredo J.
Varela, Pilar
Rodríguez-Lago, Iago
Ramos, Laura
Sempere, Laura
Sesé, Eva
Barreiro-de Acosta, Manuel
Domènech, Eugeni
Francés, Rubén
author_sort Gutiérrez, Ana
collection PubMed
description BACKGROUND: Previous studies comparing immigrant ethnic groups and native patients with IBD have yielded clinical and phenotypic differences. To date, no study has focused on the immigrant IBD population in Spain. METHODS: Prospective, observational, multicenter study comparing cohorts of IBD patients from ENEIDA-registry who were born outside Spain with a cohort of native patients. RESULTS: We included 13,524 patients (1,864 immigrant and 11,660 native). The immigrants were younger (45 ± 12 vs. 54 ± 16 years, p < 0.001), had been diagnosed younger (31 ± 12 vs. 36 ± 15 years, p < 0.001), and had a shorter disease duration (14 ± 7 vs. 18 ± 8 years, p < 0.001) than native patients. Family history of IBD (9 vs. 14%, p < 0.001) and smoking (30 vs. 40%, p < 0.001) were more frequent among native patients. The most prevalent ethnic groups among immigrants were Caucasian (41.5%), followed by Latin American (30.8%), Arab (18.3%), and Asian (6.7%). Extraintestinal manifestations, mainly musculoskeletal affections, were more frequent in immigrants (19 vs. 11%, p < 0.001). Use of biologics, mainly anti-TNF, was greater in immigrants (36 vs. 29%, p < 0.001). The risk of having extraintestinal manifestations [OR: 2.23 (1.92–2.58, p < 0.001)] and using biologics [OR: 1.13 (1.0–1.26, p = 0.042)] was independently associated with immigrant status in the multivariate analyses. CONCLUSIONS: Compared with native-born patients, first-generation-immigrant IBD patients in Spain were younger at disease onset and showed an increased risk of having extraintestinal manifestations and using biologics. Our study suggests a featured phenotype of immigrant IBD patients in Spain, and constitutes a new landmark in the epidemiological characterization of immigrant IBD populations in Southern Europe.
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spelling pubmed-88445612022-02-16 Immigrant IBD Patients in Spain Are Younger, Have More Extraintestinal Manifestations and Use More Biologics Than Native Patients Gutiérrez, Ana Zapater, Pedro Ricart, Elena González-Vivó, María Gordillo, Jordi Olivares, David Vera, Isabel Mañosa, Míriam Gisbert, Javier P. Aguas, Mariam Sánchez-Rodríguez, Eugenia Bosca-Watts, Maia Laredo, Viviana Camps, Blau Marín-Jiménez, Ignacio Zabana, Yamile Martín-Arranz, María Dolores Muñoz, Roser Navarro, Mercè Sierra, Eva Madero, Lucía Vela, Milagros Pérez-Calle, José Lázaro Sainz, Empar Calvet, Xavier Arias, Lara Morales, Victor Bermejo, Fernando Fernández-Salazar, Luis Van Domselaar, Manuel De Castro, Luisa Rodríguez, Cristina Muñoz-Villafranca, Carmen Lorente, Rufo Rivero, Montserrat Iglesias, Eva Herreros, Belén Busquets, David Riera, Joan Martínez-Montiel, María Pilar Roldón, Marta Roncero, Oscar Hinojosa, Esther Sierra, Mónica Barrio, Jesús De Francisco, Ruth Huguet, José Merino, Olga Carpio, Daniel Ginard, Daniel Muñoz, Fernando Piqueras, Marta Almela, Pedro Argüelles-Arias, Federico Alcaín, Guillermo Bujanda, Luis Manceñido, Noemí Lucendo, Alfredo J. Varela, Pilar Rodríguez-Lago, Iago Ramos, Laura Sempere, Laura Sesé, Eva Barreiro-de Acosta, Manuel Domènech, Eugeni Francés, Rubén Front Med (Lausanne) Medicine BACKGROUND: Previous studies comparing immigrant ethnic groups and native patients with IBD have yielded clinical and phenotypic differences. To date, no study has focused on the immigrant IBD population in Spain. METHODS: Prospective, observational, multicenter study comparing cohorts of IBD patients from ENEIDA-registry who were born outside Spain with a cohort of native patients. RESULTS: We included 13,524 patients (1,864 immigrant and 11,660 native). The immigrants were younger (45 ± 12 vs. 54 ± 16 years, p < 0.001), had been diagnosed younger (31 ± 12 vs. 36 ± 15 years, p < 0.001), and had a shorter disease duration (14 ± 7 vs. 18 ± 8 years, p < 0.001) than native patients. Family history of IBD (9 vs. 14%, p < 0.001) and smoking (30 vs. 40%, p < 0.001) were more frequent among native patients. The most prevalent ethnic groups among immigrants were Caucasian (41.5%), followed by Latin American (30.8%), Arab (18.3%), and Asian (6.7%). Extraintestinal manifestations, mainly musculoskeletal affections, were more frequent in immigrants (19 vs. 11%, p < 0.001). Use of biologics, mainly anti-TNF, was greater in immigrants (36 vs. 29%, p < 0.001). The risk of having extraintestinal manifestations [OR: 2.23 (1.92–2.58, p < 0.001)] and using biologics [OR: 1.13 (1.0–1.26, p = 0.042)] was independently associated with immigrant status in the multivariate analyses. CONCLUSIONS: Compared with native-born patients, first-generation-immigrant IBD patients in Spain were younger at disease onset and showed an increased risk of having extraintestinal manifestations and using biologics. Our study suggests a featured phenotype of immigrant IBD patients in Spain, and constitutes a new landmark in the epidemiological characterization of immigrant IBD populations in Southern Europe. Frontiers Media S.A. 2022-02-01 /pmc/articles/PMC8844561/ /pubmed/35178413 http://dx.doi.org/10.3389/fmed.2022.823900 Text en Copyright © 2022 Gutiérrez, Zapater, Ricart, González-Vivó, Gordillo, Olivares, Vera, Mañosa, Gisbert, Aguas, Sánchez-Rodríguez, Bosca-Watts, Laredo, Camps, Marín-Jiménez, Zabana, Martín-Arranz, Muñoz, Navarro, Sierra, Madero, Vela, Pérez-Calle, Sainz, Calvet, Arias, Morales, Bermejo, Fernández-Salazar, Van Domselaar, De Castro, Rodríguez, Muñoz-Villafranca, Lorente, Rivero, Iglesias, Herreros, Busquets, Riera, Martínez-Montiel, Roldón, Roncero, Hinojosa, Sierra, Barrio, De Francisco, Huguet, Merino, Carpio, Ginard, Muñoz, Piqueras, Almela, Argüelles-Arias, Alcaín, Bujanda, Manceñido, Lucendo, Varela, Rodríguez-Lago, Ramos, Sempere, Sesé, Barreiro-de Acosta, Domènech and Francés. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Gutiérrez, Ana
Zapater, Pedro
Ricart, Elena
González-Vivó, María
Gordillo, Jordi
Olivares, David
Vera, Isabel
Mañosa, Míriam
Gisbert, Javier P.
Aguas, Mariam
Sánchez-Rodríguez, Eugenia
Bosca-Watts, Maia
Laredo, Viviana
Camps, Blau
Marín-Jiménez, Ignacio
Zabana, Yamile
Martín-Arranz, María Dolores
Muñoz, Roser
Navarro, Mercè
Sierra, Eva
Madero, Lucía
Vela, Milagros
Pérez-Calle, José Lázaro
Sainz, Empar
Calvet, Xavier
Arias, Lara
Morales, Victor
Bermejo, Fernando
Fernández-Salazar, Luis
Van Domselaar, Manuel
De Castro, Luisa
Rodríguez, Cristina
Muñoz-Villafranca, Carmen
Lorente, Rufo
Rivero, Montserrat
Iglesias, Eva
Herreros, Belén
Busquets, David
Riera, Joan
Martínez-Montiel, María Pilar
Roldón, Marta
Roncero, Oscar
Hinojosa, Esther
Sierra, Mónica
Barrio, Jesús
De Francisco, Ruth
Huguet, José
Merino, Olga
Carpio, Daniel
Ginard, Daniel
Muñoz, Fernando
Piqueras, Marta
Almela, Pedro
Argüelles-Arias, Federico
Alcaín, Guillermo
Bujanda, Luis
Manceñido, Noemí
Lucendo, Alfredo J.
Varela, Pilar
Rodríguez-Lago, Iago
Ramos, Laura
Sempere, Laura
Sesé, Eva
Barreiro-de Acosta, Manuel
Domènech, Eugeni
Francés, Rubén
Immigrant IBD Patients in Spain Are Younger, Have More Extraintestinal Manifestations and Use More Biologics Than Native Patients
title Immigrant IBD Patients in Spain Are Younger, Have More Extraintestinal Manifestations and Use More Biologics Than Native Patients
title_full Immigrant IBD Patients in Spain Are Younger, Have More Extraintestinal Manifestations and Use More Biologics Than Native Patients
title_fullStr Immigrant IBD Patients in Spain Are Younger, Have More Extraintestinal Manifestations and Use More Biologics Than Native Patients
title_full_unstemmed Immigrant IBD Patients in Spain Are Younger, Have More Extraintestinal Manifestations and Use More Biologics Than Native Patients
title_short Immigrant IBD Patients in Spain Are Younger, Have More Extraintestinal Manifestations and Use More Biologics Than Native Patients
title_sort immigrant ibd patients in spain are younger, have more extraintestinal manifestations and use more biologics than native patients
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844561/
https://www.ncbi.nlm.nih.gov/pubmed/35178413
http://dx.doi.org/10.3389/fmed.2022.823900
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