Multiplicity adjustments in parallel-group multi-arm trials sharing a control group: Clear guidance is needed

Multi-arm, parallel-group clinical trials are an efficient way of testing several new treatments, treatment regimens or doses. However, guidance on the requirement for statistical adjustment to control for multiple comparisons (type I error) using a shared control group is unclear. We argue, based o...

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Detalles Bibliográficos
Autores principales: Molloy, Síle F., White, Ian R., Nunn, Andrew J., Hayes, Richard, Wang, Duolao, Harrison, Thomas S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844584/
https://www.ncbi.nlm.nih.gov/pubmed/34906747
http://dx.doi.org/10.1016/j.cct.2021.106656

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844584/
https://www.ncbi.nlm.nih.gov/pubmed/34906747
http://dx.doi.org/10.1016/j.cct.2021.106656

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