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Aberrant cyclin C nuclear release induces mitochondrial fragmentation and dysfunction in MED13L syndrome fibroblasts

MED13L syndrome is a haploinsufficiency developmental disorder characterized by intellectual disability, heart malformation, and hypotonia. MED13L controls transcription by tethering the cyclin C-Cdk8 kinase module (CKM) to the Mediator complex. In addition, cyclin C has CKM-independent roles in the...

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Detalles Bibliográficos
Autores principales:	Chang, Kai-Ti, Jezek, Jan, Campbell, Alicia N., Stieg, David C., Kiss, Zachary A., Kemper, Kevin, Jiang, Ping, Lee, Hyung-Ok, Kruger, Warren D., van Hasselt, Peter M., Strich, Randy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844603/ https://www.ncbi.nlm.nih.gov/pubmed/35198885 http://dx.doi.org/10.1016/j.isci.2022.103823

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