Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response

To overcome oxidative, inflammatory, and metabolic stress, cells have evolved cytoprotective protein networks controlled by nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) and its negative regulator, Kelch-like ECH associated protein 1 (Keap1). Here, using high-resolution mass spectrometry we...

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Detalles Bibliográficos
Autores principales: Ryan, Dylan G., Knatko, Elena V., Casey, Alva M., Hukelmann, Jens L., Dayalan Naidu, Sharadha, Brenes, Alejandro J., Ekkunagul, Thanapon, Baker, Christa, Higgins, Maureen, Tronci, Laura, Nikitopolou, Efterpi, Honda, Tadashi, Hartley, Richard C., O’Neill, Luke A.J., Frezza, Christian, Lamond, Angus I., Abramov, Andrey Y., Arthur, J. Simon C., Cantrell, Doreen A., Murphy, Michael P., Dinkova-Kostova, Albena T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844662/
https://www.ncbi.nlm.nih.gov/pubmed/35198887
http://dx.doi.org/10.1016/j.isci.2022.103827

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