Severity of adverse reactions is associated with T-cell response in mRNA-1273 vaccinated health care workers

Knowledge about mRNA-1273 elicited T-cell response is limited. We investigated adverse reactions and interferon gamma release by specific T-cells among mRNA-1273 vaccinated health care workers. Seven to 13 weeks after complete vaccination low levels of specific T-cells were detected not correlating...

Descripción completa

Detalles Bibliográficos
Autores principales: Klingel, Hanna, Lauen, Maike, Krüttgen, Alexander, Imöhl, Matthias, Kleines, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Vaccine Society 2022
Materias:
Covid-19 Special
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844663/
https://www.ncbi.nlm.nih.gov/pubmed/35223673
http://dx.doi.org/10.7774/cevr.2022.11.1.121
_version_ 1784651520623509504
author Klingel, Hanna
Lauen, Maike
Krüttgen, Alexander
Imöhl, Matthias
Kleines, Michael
author_facet Klingel, Hanna
Lauen, Maike
Krüttgen, Alexander
Imöhl, Matthias
Kleines, Michael
author_sort Klingel, Hanna
collection PubMed
description Knowledge about mRNA-1273 elicited T-cell response is limited. We investigated adverse reactions and interferon gamma release by specific T-cells among mRNA-1273 vaccinated health care workers. Seven to 13 weeks after complete vaccination low levels of specific T-cells were detected not correlating with antibody response. Severity of symptoms after first and number of symptoms after second immunization were associated with T-cell response. Assessment of T-cell response in addition to antibody response is crucial because even few specific T-cells could add to protection against infection. Investigation of mRNA-1273 induced inflammatory processes might help improve reactogenicity and immunogenicity.
format Online
Article
Text
id pubmed-8844663
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher The Korean Vaccine Society
record_format MEDLINE/PubMed
spelling pubmed-88446632022-02-24 Severity of adverse reactions is associated with T-cell response in mRNA-1273 vaccinated health care workers Klingel, Hanna Lauen, Maike Krüttgen, Alexander Imöhl, Matthias Kleines, Michael Clin Exp Vaccine Res Covid-19 Special Knowledge about mRNA-1273 elicited T-cell response is limited. We investigated adverse reactions and interferon gamma release by specific T-cells among mRNA-1273 vaccinated health care workers. Seven to 13 weeks after complete vaccination low levels of specific T-cells were detected not correlating with antibody response. Severity of symptoms after first and number of symptoms after second immunization were associated with T-cell response. Assessment of T-cell response in addition to antibody response is crucial because even few specific T-cells could add to protection against infection. Investigation of mRNA-1273 induced inflammatory processes might help improve reactogenicity and immunogenicity. The Korean Vaccine Society 2022-01 2022-01-31 /pmc/articles/PMC8844663/ /pubmed/35223673 http://dx.doi.org/10.7774/cevr.2022.11.1.121 Text en © Korean Vaccine Society. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Covid-19 Special
Klingel, Hanna
Lauen, Maike
Krüttgen, Alexander
Imöhl, Matthias
Kleines, Michael
Severity of adverse reactions is associated with T-cell response in mRNA-1273 vaccinated health care workers
title Severity of adverse reactions is associated with T-cell response in mRNA-1273 vaccinated health care workers
title_full Severity of adverse reactions is associated with T-cell response in mRNA-1273 vaccinated health care workers
title_fullStr Severity of adverse reactions is associated with T-cell response in mRNA-1273 vaccinated health care workers
title_full_unstemmed Severity of adverse reactions is associated with T-cell response in mRNA-1273 vaccinated health care workers
title_short Severity of adverse reactions is associated with T-cell response in mRNA-1273 vaccinated health care workers
title_sort severity of adverse reactions is associated with t-cell response in mrna-1273 vaccinated health care workers
topic Covid-19 Special
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844663/
https://www.ncbi.nlm.nih.gov/pubmed/35223673
http://dx.doi.org/10.7774/cevr.2022.11.1.121
work_keys_str_mv AT klingelhanna severityofadversereactionsisassociatedwithtcellresponseinmrna1273vaccinatedhealthcareworkers
AT lauenmaike severityofadversereactionsisassociatedwithtcellresponseinmrna1273vaccinatedhealthcareworkers
AT kruttgenalexander severityofadversereactionsisassociatedwithtcellresponseinmrna1273vaccinatedhealthcareworkers
AT imohlmatthias severityofadversereactionsisassociatedwithtcellresponseinmrna1273vaccinatedhealthcareworkers
AT kleinesmichael severityofadversereactionsisassociatedwithtcellresponseinmrna1273vaccinatedhealthcareworkers

Ejemplares similares