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Assessment on anti-SARS-CoV-2 receptor-binding domain antibodies among CoronaVac-vaccinated Indonesian adults
The immunogenicity of CoronaVac among Indonesian adults at the academic premises was investigated. Two doses of CoronaVac vaccine induced a complete seroconversion on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) naïve adults with titers of anti-SARS-CoV-2 receptor-binding domain (RBD...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Vaccine Society
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844676/ https://www.ncbi.nlm.nih.gov/pubmed/35223672 http://dx.doi.org/10.7774/cevr.2022.11.1.116 |
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author | Jo, Juandy Sanjaya, Astia Pinontoan, Reinhard Aruan, Maroloan Wahyuni, Rury Mega Viktaria, Venansi |
author_facet | Jo, Juandy Sanjaya, Astia Pinontoan, Reinhard Aruan, Maroloan Wahyuni, Rury Mega Viktaria, Venansi |
author_sort | Jo, Juandy |
collection | PubMed |
description | The immunogenicity of CoronaVac among Indonesian adults at the academic premises was investigated. Two doses of CoronaVac vaccine induced a complete seroconversion on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) naïve adults with titers of anti-SARS-CoV-2 receptor-binding domain (RBD) antibodies ranging from 9.1 to 151.9 U/mL. The median value was lower than the one observed in recovered adults with mild coronavirus disease 2019 (38.7 vs. 114.5 U/mL). Nonetheless, 93.6% of the vaccinated adults, in contrast to 76.5% of the recovered adults, displayed inhibition rates above the cut-off to block RBD-angiotensin-converting enzyme 2 binding. This suggests that two doses of CoronaVac were immunogenic and likely to be protective among Indonesian adults. |
format | Online Article Text |
id | pubmed-8844676 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Korean Vaccine Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-88446762022-02-24 Assessment on anti-SARS-CoV-2 receptor-binding domain antibodies among CoronaVac-vaccinated Indonesian adults Jo, Juandy Sanjaya, Astia Pinontoan, Reinhard Aruan, Maroloan Wahyuni, Rury Mega Viktaria, Venansi Clin Exp Vaccine Res COVID-19 Special The immunogenicity of CoronaVac among Indonesian adults at the academic premises was investigated. Two doses of CoronaVac vaccine induced a complete seroconversion on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) naïve adults with titers of anti-SARS-CoV-2 receptor-binding domain (RBD) antibodies ranging from 9.1 to 151.9 U/mL. The median value was lower than the one observed in recovered adults with mild coronavirus disease 2019 (38.7 vs. 114.5 U/mL). Nonetheless, 93.6% of the vaccinated adults, in contrast to 76.5% of the recovered adults, displayed inhibition rates above the cut-off to block RBD-angiotensin-converting enzyme 2 binding. This suggests that two doses of CoronaVac were immunogenic and likely to be protective among Indonesian adults. The Korean Vaccine Society 2022-01 2022-01-31 /pmc/articles/PMC8844676/ /pubmed/35223672 http://dx.doi.org/10.7774/cevr.2022.11.1.116 Text en © Korean Vaccine Society. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | COVID-19 Special Jo, Juandy Sanjaya, Astia Pinontoan, Reinhard Aruan, Maroloan Wahyuni, Rury Mega Viktaria, Venansi Assessment on anti-SARS-CoV-2 receptor-binding domain antibodies among CoronaVac-vaccinated Indonesian adults |
title | Assessment on anti-SARS-CoV-2 receptor-binding domain antibodies among CoronaVac-vaccinated Indonesian adults |
title_full | Assessment on anti-SARS-CoV-2 receptor-binding domain antibodies among CoronaVac-vaccinated Indonesian adults |
title_fullStr | Assessment on anti-SARS-CoV-2 receptor-binding domain antibodies among CoronaVac-vaccinated Indonesian adults |
title_full_unstemmed | Assessment on anti-SARS-CoV-2 receptor-binding domain antibodies among CoronaVac-vaccinated Indonesian adults |
title_short | Assessment on anti-SARS-CoV-2 receptor-binding domain antibodies among CoronaVac-vaccinated Indonesian adults |
title_sort | assessment on anti-sars-cov-2 receptor-binding domain antibodies among coronavac-vaccinated indonesian adults |
topic | COVID-19 Special |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844676/ https://www.ncbi.nlm.nih.gov/pubmed/35223672 http://dx.doi.org/10.7774/cevr.2022.11.1.116 |
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