Cargando…

Assessment on anti-SARS-CoV-2 receptor-binding domain antibodies among CoronaVac-vaccinated Indonesian adults

The immunogenicity of CoronaVac among Indonesian adults at the academic premises was investigated. Two doses of CoronaVac vaccine induced a complete seroconversion on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) naïve adults with titers of anti-SARS-CoV-2 receptor-binding domain (RBD...

Descripción completa

Detalles Bibliográficos
Autores principales: Jo, Juandy, Sanjaya, Astia, Pinontoan, Reinhard, Aruan, Maroloan, Wahyuni, Rury Mega, Viktaria, Venansi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Vaccine Society 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844676/
https://www.ncbi.nlm.nih.gov/pubmed/35223672
http://dx.doi.org/10.7774/cevr.2022.11.1.116
_version_ 1784651523794403328
author Jo, Juandy
Sanjaya, Astia
Pinontoan, Reinhard
Aruan, Maroloan
Wahyuni, Rury Mega
Viktaria, Venansi
author_facet Jo, Juandy
Sanjaya, Astia
Pinontoan, Reinhard
Aruan, Maroloan
Wahyuni, Rury Mega
Viktaria, Venansi
author_sort Jo, Juandy
collection PubMed
description The immunogenicity of CoronaVac among Indonesian adults at the academic premises was investigated. Two doses of CoronaVac vaccine induced a complete seroconversion on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) naïve adults with titers of anti-SARS-CoV-2 receptor-binding domain (RBD) antibodies ranging from 9.1 to 151.9 U/mL. The median value was lower than the one observed in recovered adults with mild coronavirus disease 2019 (38.7 vs. 114.5 U/mL). Nonetheless, 93.6% of the vaccinated adults, in contrast to 76.5% of the recovered adults, displayed inhibition rates above the cut-off to block RBD-angiotensin-converting enzyme 2 binding. This suggests that two doses of CoronaVac were immunogenic and likely to be protective among Indonesian adults.
format Online
Article
Text
id pubmed-8844676
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher The Korean Vaccine Society
record_format MEDLINE/PubMed
spelling pubmed-88446762022-02-24 Assessment on anti-SARS-CoV-2 receptor-binding domain antibodies among CoronaVac-vaccinated Indonesian adults Jo, Juandy Sanjaya, Astia Pinontoan, Reinhard Aruan, Maroloan Wahyuni, Rury Mega Viktaria, Venansi Clin Exp Vaccine Res COVID-19 Special The immunogenicity of CoronaVac among Indonesian adults at the academic premises was investigated. Two doses of CoronaVac vaccine induced a complete seroconversion on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) naïve adults with titers of anti-SARS-CoV-2 receptor-binding domain (RBD) antibodies ranging from 9.1 to 151.9 U/mL. The median value was lower than the one observed in recovered adults with mild coronavirus disease 2019 (38.7 vs. 114.5 U/mL). Nonetheless, 93.6% of the vaccinated adults, in contrast to 76.5% of the recovered adults, displayed inhibition rates above the cut-off to block RBD-angiotensin-converting enzyme 2 binding. This suggests that two doses of CoronaVac were immunogenic and likely to be protective among Indonesian adults. The Korean Vaccine Society 2022-01 2022-01-31 /pmc/articles/PMC8844676/ /pubmed/35223672 http://dx.doi.org/10.7774/cevr.2022.11.1.116 Text en © Korean Vaccine Society. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle COVID-19 Special
Jo, Juandy
Sanjaya, Astia
Pinontoan, Reinhard
Aruan, Maroloan
Wahyuni, Rury Mega
Viktaria, Venansi
Assessment on anti-SARS-CoV-2 receptor-binding domain antibodies among CoronaVac-vaccinated Indonesian adults
title Assessment on anti-SARS-CoV-2 receptor-binding domain antibodies among CoronaVac-vaccinated Indonesian adults
title_full Assessment on anti-SARS-CoV-2 receptor-binding domain antibodies among CoronaVac-vaccinated Indonesian adults
title_fullStr Assessment on anti-SARS-CoV-2 receptor-binding domain antibodies among CoronaVac-vaccinated Indonesian adults
title_full_unstemmed Assessment on anti-SARS-CoV-2 receptor-binding domain antibodies among CoronaVac-vaccinated Indonesian adults
title_short Assessment on anti-SARS-CoV-2 receptor-binding domain antibodies among CoronaVac-vaccinated Indonesian adults
title_sort assessment on anti-sars-cov-2 receptor-binding domain antibodies among coronavac-vaccinated indonesian adults
topic COVID-19 Special
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844676/
https://www.ncbi.nlm.nih.gov/pubmed/35223672
http://dx.doi.org/10.7774/cevr.2022.11.1.116
work_keys_str_mv AT jojuandy assessmentonantisarscov2receptorbindingdomainantibodiesamongcoronavacvaccinatedindonesianadults
AT sanjayaastia assessmentonantisarscov2receptorbindingdomainantibodiesamongcoronavacvaccinatedindonesianadults
AT pinontoanreinhard assessmentonantisarscov2receptorbindingdomainantibodiesamongcoronavacvaccinatedindonesianadults
AT aruanmaroloan assessmentonantisarscov2receptorbindingdomainantibodiesamongcoronavacvaccinatedindonesianadults
AT wahyunirurymega assessmentonantisarscov2receptorbindingdomainantibodiesamongcoronavacvaccinatedindonesianadults
AT viktariavenansi assessmentonantisarscov2receptorbindingdomainantibodiesamongcoronavacvaccinatedindonesianadults