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Spinal nocardiosis: A rare tuberculosis mimic in an HIV infected patient

Despite advances in treatment, human immunodeficiency virus/tuberculosis (HIV/TB) coinfection remains highly prevalent in selected low- and middle income countries. The diagnosis of tuberculosis frequently proves challenging in the setting of advanced HIV, as patients may present with atypical featu...

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Autores principales: Knoetzen, Monique, Robbertse, Pieter-Paul Straus, Parker, Arifa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844763/
https://www.ncbi.nlm.nih.gov/pubmed/35198387
http://dx.doi.org/10.1016/j.idcr.2022.e01444
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author Knoetzen, Monique
Robbertse, Pieter-Paul Straus
Parker, Arifa
author_facet Knoetzen, Monique
Robbertse, Pieter-Paul Straus
Parker, Arifa
author_sort Knoetzen, Monique
collection PubMed
description Despite advances in treatment, human immunodeficiency virus/tuberculosis (HIV/TB) coinfection remains highly prevalent in selected low- and middle income countries. The diagnosis of tuberculosis frequently proves challenging in the setting of advanced HIV, as patients may present with atypical features. A high index of suspicion must be maintained for TB in this setting, but it is critical that alternative diagnoses are considered. A myriad of opportunistic infections may mimic TB and a definitive microbiological diagnosis prior to TB treatment should always be sought. We report on a case of a young, HIV positive male who presented with a delayed diagnosis of nocardiosis that was thought to be TB of the spine. Despite extensive laboratory and radiological investigations, the diagnosis was only made after tissue was cultured. Earlier diagnosis of this mimic would have led to appropriate therapy and may have improved the outcome for this patient.
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spelling pubmed-88447632022-02-22 Spinal nocardiosis: A rare tuberculosis mimic in an HIV infected patient Knoetzen, Monique Robbertse, Pieter-Paul Straus Parker, Arifa IDCases Case Report Despite advances in treatment, human immunodeficiency virus/tuberculosis (HIV/TB) coinfection remains highly prevalent in selected low- and middle income countries. The diagnosis of tuberculosis frequently proves challenging in the setting of advanced HIV, as patients may present with atypical features. A high index of suspicion must be maintained for TB in this setting, but it is critical that alternative diagnoses are considered. A myriad of opportunistic infections may mimic TB and a definitive microbiological diagnosis prior to TB treatment should always be sought. We report on a case of a young, HIV positive male who presented with a delayed diagnosis of nocardiosis that was thought to be TB of the spine. Despite extensive laboratory and radiological investigations, the diagnosis was only made after tissue was cultured. Earlier diagnosis of this mimic would have led to appropriate therapy and may have improved the outcome for this patient. Elsevier 2022-02-04 /pmc/articles/PMC8844763/ /pubmed/35198387 http://dx.doi.org/10.1016/j.idcr.2022.e01444 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Knoetzen, Monique
Robbertse, Pieter-Paul Straus
Parker, Arifa
Spinal nocardiosis: A rare tuberculosis mimic in an HIV infected patient
title Spinal nocardiosis: A rare tuberculosis mimic in an HIV infected patient
title_full Spinal nocardiosis: A rare tuberculosis mimic in an HIV infected patient
title_fullStr Spinal nocardiosis: A rare tuberculosis mimic in an HIV infected patient
title_full_unstemmed Spinal nocardiosis: A rare tuberculosis mimic in an HIV infected patient
title_short Spinal nocardiosis: A rare tuberculosis mimic in an HIV infected patient
title_sort spinal nocardiosis: a rare tuberculosis mimic in an hiv infected patient
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844763/
https://www.ncbi.nlm.nih.gov/pubmed/35198387
http://dx.doi.org/10.1016/j.idcr.2022.e01444
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