Mechanistic impact of oligomer poisoning by dominant-negative CARD11 variants

The CARD11 scaffold controls antigen receptor signaling to NF-κB, JNK, and mTOR. Three classes of germline mutations in CARD11 cause Primary Immunodeficiency, including homozygous loss-of-function (LOF) mutations in CARD11 deficiency, heterozygous gain-of-function (GOF) mutations in BENTA disease, a...

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Detalles Bibliográficos
Autores principales: Bedsaul, Jacquelyn R., Shah, Neha, Hutcherson, Shelby M., Pomerantz, Joel L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844825/
https://www.ncbi.nlm.nih.gov/pubmed/35198875
http://dx.doi.org/10.1016/j.isci.2022.103810

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844825/
https://www.ncbi.nlm.nih.gov/pubmed/35198875
http://dx.doi.org/10.1016/j.isci.2022.103810

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