Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency

Haploinsufficiency of the progranulin (PGRN)‐encoding gene (GRN) causes frontotemporal lobar degeneration (GRN‐FTLD) and results in microglial hyperactivation, TREM2 activation, lysosomal dysfunction, and TDP‐43 deposition. To understand the contribution of microglial hyperactivation to pathology, w...

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Detalles Bibliográficos
Autores principales: Reifschneider, Anika, Robinson, Sophie, van Lengerich, Bettina, Gnörich, Johannes, Logan, Todd, Heindl, Steffanie, Vogt, Miriam A, Weidinger, Endy, Riedl, Lina, Wind, Karin, Zatcepin, Artem, Pesämaa, Ida, Haberl, Sophie, Nuscher, Brigitte, Kleinberger, Gernot, Klimmt, Julien, Götzl, Julia K, Liesz, Arthur, Bürger, Katharina, Brendel, Matthias, Levin, Johannes, Diehl‐Schmid, Janine, Suh, Jung, Di Paolo, Gilbert, Lewcock, Joseph W, Monroe, Kathryn M, Paquet, Dominik, Capell, Anja, Haass, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844989/
https://www.ncbi.nlm.nih.gov/pubmed/35019161
http://dx.doi.org/10.15252/embj.2021109108

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