Cu(I)-Catalyzed Alkynylation of Quinolones

[Image: see text] Herein we report the first alkynylation of quinolones with terminal alkynes under mild reaction conditions. The reaction is catalyzed by Cu(I) salts in the presence of a Lewis acid, which is essential for the reactivity of the system. The enantioselective version of this transforma...

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Autores principales: Maestro, Aitor, Lemaire, Sebastien, Harutyunyan, Syuzanna R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8845045/
https://www.ncbi.nlm.nih.gov/pubmed/35099185
http://dx.doi.org/10.1021/acs.orglett.2c00020
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author Maestro, Aitor
Lemaire, Sebastien
Harutyunyan, Syuzanna R.
author_facet Maestro, Aitor
Lemaire, Sebastien
Harutyunyan, Syuzanna R.
author_sort Maestro, Aitor
collection PubMed
description [Image: see text] Herein we report the first alkynylation of quinolones with terminal alkynes under mild reaction conditions. The reaction is catalyzed by Cu(I) salts in the presence of a Lewis acid, which is essential for the reactivity of the system. The enantioselective version of this transformation has also been explored, and the methodology has been applied in the synthesis of the enantioenriched tetrahydroquinoline alkaloid cuspareine.
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spelling pubmed-88450452022-02-15 Cu(I)-Catalyzed Alkynylation of Quinolones Maestro, Aitor Lemaire, Sebastien Harutyunyan, Syuzanna R. Org Lett [Image: see text] Herein we report the first alkynylation of quinolones with terminal alkynes under mild reaction conditions. The reaction is catalyzed by Cu(I) salts in the presence of a Lewis acid, which is essential for the reactivity of the system. The enantioselective version of this transformation has also been explored, and the methodology has been applied in the synthesis of the enantioenriched tetrahydroquinoline alkaloid cuspareine. American Chemical Society 2022-01-31 2022-02-11 /pmc/articles/PMC8845045/ /pubmed/35099185 http://dx.doi.org/10.1021/acs.orglett.2c00020 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Maestro, Aitor
Lemaire, Sebastien
Harutyunyan, Syuzanna R.
Cu(I)-Catalyzed Alkynylation of Quinolones
title Cu(I)-Catalyzed Alkynylation of Quinolones
title_full Cu(I)-Catalyzed Alkynylation of Quinolones
title_fullStr Cu(I)-Catalyzed Alkynylation of Quinolones
title_full_unstemmed Cu(I)-Catalyzed Alkynylation of Quinolones
title_short Cu(I)-Catalyzed Alkynylation of Quinolones
title_sort cu(i)-catalyzed alkynylation of quinolones
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8845045/
https://www.ncbi.nlm.nih.gov/pubmed/35099185
http://dx.doi.org/10.1021/acs.orglett.2c00020
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AT lemairesebastien cuicatalyzedalkynylationofquinolones
AT harutyunyansyuzannar cuicatalyzedalkynylationofquinolones

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