Etoposide-induced DNA damage is increased in p53 mutants: identification of ATR and other genes that influence effects of p53 mutations on Top2-induced cytotoxicity

The functional status of the tumor suppressor p53 is a critical component in determining the sensitivity of cancer cells to many chemotherapeutic agents. DNA topoisomerase II (Top2) plays essential roles in DNA metabolism and is the target of FDA approved chemotherapeutic agents. Topoisomerase targe...

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Detalles Bibliográficos
Autores principales: Menendez, Daniel, Anand, Jay R., Murphy, Carri C., Bell, Whitney J., Fu, Jiaqi, Slepushkina, Nadia, Buehler, Eugen, Martin, Scott E., Lal-Nag, Madhu, Nitiss, John L., Resnick, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8845119/
https://www.ncbi.nlm.nih.gov/pubmed/35178190
http://dx.doi.org/10.18632/oncotarget.28195

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