Sex-biased islet β cell dysfunction is caused by the MODY MAFA S64F variant by inducing premature aging and senescence in males

A heterozygous missense mutation of the islet β cell-enriched MAFA transcription factor (p.Ser64Phe [S64F]) is found in patients with adult-onset β cell dysfunction (diabetes or insulinomatosis), with men more prone to diabetes than women. This mutation engenders increased stability to the unstable...

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Detalles Bibliográficos
Autores principales: Walker, Emily M., Cha, Jeeyeon, Tong, Xin, Guo, Min, Liu, Jin-Hua, Yu, Sophia, Iacovazzo, Donato, Mauvais-Jarvis, Franck, Flanagan, Sarah E., Korbonits, Márta, Stafford, John, Jacobson, David A., Stein, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8845126/
https://www.ncbi.nlm.nih.gov/pubmed/34644565
http://dx.doi.org/10.1016/j.celrep.2021.109813

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