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Metabolic Dysfunction-associated Fatty Liver Disease (MAFLD) and Viral Hepatitis

A new definition of metabolic dysfunction-associated fatty liver disease (MAFLD) was proposed in 2020. The change from nonalcoholic fatty liver disease (NAFLD) to MAFLD highlights the metabolic abnormalities that accompany fatty liver. The diagnosis of MAFLD does not require exclusion of secondary c...

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Detalles Bibliográficos
Autores principales: Wang, Xiaolin, Xie, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: XIA & HE Publishing Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8845159/
https://www.ncbi.nlm.nih.gov/pubmed/35233381
http://dx.doi.org/10.14218/JCTH.2021.00200
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author Wang, Xiaolin
Xie, Qing
author_facet Wang, Xiaolin
Xie, Qing
author_sort Wang, Xiaolin
collection PubMed
description A new definition of metabolic dysfunction-associated fatty liver disease (MAFLD) was proposed in 2020. The change from nonalcoholic fatty liver disease (NAFLD) to MAFLD highlights the metabolic abnormalities that accompany fatty liver. The diagnosis of MAFLD does not require exclusion of secondary causes of liver diseases and alcohol consumption. Thus, MAFLD may coexist with other types of liver diseases, such as viral hepatitis, a disease that remains the most common cause of liver disease-related death. With the increasing prevalence of MAFLD, patients with coincidental MAFLD and viral hepatitis are frequently encountered in clinical practice. In this review, we mainly summarize the mutual relationship between hepatitis B/C and systematic metabolism dysfunction related to MAFLD. We discuss the impact of MAFLD on progression of viral hepatitis and the therapies. Some unaddressed clinical problems related to concomitant MAFLD and viral hepatitis are also identified.
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spelling pubmed-88451592022-02-28 Metabolic Dysfunction-associated Fatty Liver Disease (MAFLD) and Viral Hepatitis Wang, Xiaolin Xie, Qing J Clin Transl Hepatol Review Article A new definition of metabolic dysfunction-associated fatty liver disease (MAFLD) was proposed in 2020. The change from nonalcoholic fatty liver disease (NAFLD) to MAFLD highlights the metabolic abnormalities that accompany fatty liver. The diagnosis of MAFLD does not require exclusion of secondary causes of liver diseases and alcohol consumption. Thus, MAFLD may coexist with other types of liver diseases, such as viral hepatitis, a disease that remains the most common cause of liver disease-related death. With the increasing prevalence of MAFLD, patients with coincidental MAFLD and viral hepatitis are frequently encountered in clinical practice. In this review, we mainly summarize the mutual relationship between hepatitis B/C and systematic metabolism dysfunction related to MAFLD. We discuss the impact of MAFLD on progression of viral hepatitis and the therapies. Some unaddressed clinical problems related to concomitant MAFLD and viral hepatitis are also identified. XIA & HE Publishing Inc. 2022-02-28 2021-10-08 /pmc/articles/PMC8845159/ /pubmed/35233381 http://dx.doi.org/10.14218/JCTH.2021.00200 Text en © 2022 Authors. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Wang, Xiaolin
Xie, Qing
Metabolic Dysfunction-associated Fatty Liver Disease (MAFLD) and Viral Hepatitis
title Metabolic Dysfunction-associated Fatty Liver Disease (MAFLD) and Viral Hepatitis
title_full Metabolic Dysfunction-associated Fatty Liver Disease (MAFLD) and Viral Hepatitis
title_fullStr Metabolic Dysfunction-associated Fatty Liver Disease (MAFLD) and Viral Hepatitis
title_full_unstemmed Metabolic Dysfunction-associated Fatty Liver Disease (MAFLD) and Viral Hepatitis
title_short Metabolic Dysfunction-associated Fatty Liver Disease (MAFLD) and Viral Hepatitis
title_sort metabolic dysfunction-associated fatty liver disease (mafld) and viral hepatitis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8845159/
https://www.ncbi.nlm.nih.gov/pubmed/35233381
http://dx.doi.org/10.14218/JCTH.2021.00200
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