Boosting with Omicron-matched or historical mRNA vaccines increases neutralizing antibody responses and protection against B.1.1.529 infection in mice

The B.1.1.529 Omicron variant jeopardizes vaccines designed with early pandemic spike antigens. Here, we evaluated in mice the protective activity of the Moderna mRNA-1273 vaccine against B.1.1.529 before or after boosting with preclinical mRNA-1273 or mRNA-1273.529, an Omicron-matched vaccine. Wher...

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Detalles Bibliográficos
Autores principales: Ying, Baoling, Scheaffer, Suzanne M., Whitener, Bradley, Liang, Chieh-Yu, Dmytrenko, Oleksandr, Mackin, Samantha, Wu, Kai, Lee, Diana, Avena, Laura E., Chong, Zhenlu, Case, James Brett, Ma, LingZhi, Kim, Thu, Sein, Caralyn, Woods, Angela, Berrueta, Daniela Montes, Carfi, Andrea, Elbashir, Sayda M., Edwards, Darin K., Thackray, Larissa B., Diamond, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8845417/
https://www.ncbi.nlm.nih.gov/pubmed/35169795
http://dx.doi.org/10.1101/2022.02.07.479419

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