The mechanisms of catalysis and ligand binding for the SARS-CoV-2 NSP3 macrodomain from neutron and X-ray diffraction at room temperature

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The NSP3 macrodomain of SARS CoV 2 (Mac1) removes ADP-ribosylation post-translational modifications, playing a key role in the immune evasion capabilities of the virus responsible for the COVID-19 pandemic. Here, we determined neutron and X-ray crystal structures of the SARS-CoV-2 NSP3 macrodomain u...

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Detalles Bibliográficos
Autores principales: Correy, Galen J., Kneller, Daniel W., Phillips, Gwyndalyn, Pant, Swati, Russi, Silvia, Cohen, Aina E., Meigs, George, Holton, James M., Gahbauer, Stefan, Thompson, Michael C., Ashworth, Alan, Coates, Leighton, Kovalevsky, Andrey, Meilleur, Flora, Fraser, James S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8845425/
https://www.ncbi.nlm.nih.gov/pubmed/35169801
http://dx.doi.org/10.1101/2022.02.07.479477
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