Activity of Oritavancin against Gram-Positive Pathogens Causing Bloodstream Infections in the United States over 10 Years: Focus on Drug-Resistant Enterococcal Subsets (2010–2019)

Oritavancin displayed potent and stable activity (MIC(90) range of 0.06 to 0.5 mg/L) over a 10-year period (2010 to 2019) against Gram-positive pathogens that cause bloodstream infections (BSI), including methicillin-resistant Staphylococcus aureus (MRSA) and resistant subsets of Enterococcus spp. D...

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Autores principales: Carvalhaes, Cecilia G., Sader, Helio S., Streit, Jennifer M., Castanheira, Mariana, Mendes, Rodrigo E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Epidemiology and Surveillance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8846398/
https://www.ncbi.nlm.nih.gov/pubmed/34807761
http://dx.doi.org/10.1128/AAC.01667-21
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author Carvalhaes, Cecilia G.
Sader, Helio S.
Streit, Jennifer M.
Castanheira, Mariana
Mendes, Rodrigo E.
author_facet Carvalhaes, Cecilia G.
Sader, Helio S.
Streit, Jennifer M.
Castanheira, Mariana
Mendes, Rodrigo E.
author_sort Carvalhaes, Cecilia G.
collection PubMed
description Oritavancin displayed potent and stable activity (MIC(90) range of 0.06 to 0.5 mg/L) over a 10-year period (2010 to 2019) against Gram-positive pathogens that cause bloodstream infections (BSI), including methicillin-resistant Staphylococcus aureus (MRSA) and resistant subsets of Enterococcus spp. Daptomycin and linezolid were also active against methicillin-resistant S. aureus and vancomycin-resistant Enterococcus (VRE). Only oritavancin and linezolid remained active against Enterococcus faecium isolates displaying an elevated daptomycin MIC (i.e., 2 to 4 mg/L). Proportions of methicillin-resistant S. aureus and vancomycin-resistant Enterococcus within the respective S. aureus and enterococcal populations decreased over this period.
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spelling pubmed-88463982022-03-03 Activity of Oritavancin against Gram-Positive Pathogens Causing Bloodstream Infections in the United States over 10 Years: Focus on Drug-Resistant Enterococcal Subsets (2010–2019) Carvalhaes, Cecilia G. Sader, Helio S. Streit, Jennifer M. Castanheira, Mariana Mendes, Rodrigo E. Antimicrob Agents Chemother Epidemiology and Surveillance Oritavancin displayed potent and stable activity (MIC(90) range of 0.06 to 0.5 mg/L) over a 10-year period (2010 to 2019) against Gram-positive pathogens that cause bloodstream infections (BSI), including methicillin-resistant Staphylococcus aureus (MRSA) and resistant subsets of Enterococcus spp. Daptomycin and linezolid were also active against methicillin-resistant S. aureus and vancomycin-resistant Enterococcus (VRE). Only oritavancin and linezolid remained active against Enterococcus faecium isolates displaying an elevated daptomycin MIC (i.e., 2 to 4 mg/L). Proportions of methicillin-resistant S. aureus and vancomycin-resistant Enterococcus within the respective S. aureus and enterococcal populations decreased over this period. American Society for Microbiology 2022-02-15 /pmc/articles/PMC8846398/ /pubmed/34807761 http://dx.doi.org/10.1128/AAC.01667-21 Text en Copyright © 2022 Carvalhaes et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Epidemiology and Surveillance
Carvalhaes, Cecilia G.
Sader, Helio S.
Streit, Jennifer M.
Castanheira, Mariana
Mendes, Rodrigo E.
Activity of Oritavancin against Gram-Positive Pathogens Causing Bloodstream Infections in the United States over 10 Years: Focus on Drug-Resistant Enterococcal Subsets (2010–2019)
title Activity of Oritavancin against Gram-Positive Pathogens Causing Bloodstream Infections in the United States over 10 Years: Focus on Drug-Resistant Enterococcal Subsets (2010–2019)
title_full Activity of Oritavancin against Gram-Positive Pathogens Causing Bloodstream Infections in the United States over 10 Years: Focus on Drug-Resistant Enterococcal Subsets (2010–2019)
title_fullStr Activity of Oritavancin against Gram-Positive Pathogens Causing Bloodstream Infections in the United States over 10 Years: Focus on Drug-Resistant Enterococcal Subsets (2010–2019)
title_full_unstemmed Activity of Oritavancin against Gram-Positive Pathogens Causing Bloodstream Infections in the United States over 10 Years: Focus on Drug-Resistant Enterococcal Subsets (2010–2019)
title_short Activity of Oritavancin against Gram-Positive Pathogens Causing Bloodstream Infections in the United States over 10 Years: Focus on Drug-Resistant Enterococcal Subsets (2010–2019)
title_sort activity of oritavancin against gram-positive pathogens causing bloodstream infections in the united states over 10 years: focus on drug-resistant enterococcal subsets (2010–2019)
topic Epidemiology and Surveillance
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8846398/
https://www.ncbi.nlm.nih.gov/pubmed/34807761
http://dx.doi.org/10.1128/AAC.01667-21
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