Cargando…
In Vitro Activity of Gepotidacin against Gram-Negative and Gram-Positive Anaerobes
Gepotidacin (formerly GSK2140944) is a first-in-class triazaacenaphthylene antibacterial currently in phase III clinical trials. When tested against Gram-negative (n = 333) and Gram-positive (n = 225) anaerobes by agar dilution, gepotidacin inhibited 90% of isolates at concentrations of 4 and 2 μg/m...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8846401/ https://www.ncbi.nlm.nih.gov/pubmed/34930028 http://dx.doi.org/10.1128/aac.02165-21 |
_version_ | 1784651845511151616 |
---|---|
author | Hackel, Meredith A. Karlowsky, James A. Canino, Michele A. Sahm, Daniel F. Scangarella-Oman, Nicole E. |
author_facet | Hackel, Meredith A. Karlowsky, James A. Canino, Michele A. Sahm, Daniel F. Scangarella-Oman, Nicole E. |
author_sort | Hackel, Meredith A. |
collection | PubMed |
description | Gepotidacin (formerly GSK2140944) is a first-in-class triazaacenaphthylene antibacterial currently in phase III clinical trials. When tested against Gram-negative (n = 333) and Gram-positive (n = 225) anaerobes by agar dilution, gepotidacin inhibited 90% of isolates at concentrations of 4 and 2 μg/mL, respectively. Given gepotidacin’s in vitro activity against the anaerobic isolates tested, further study is warranted to better understand the utility of gepotidacin in the treatment of infections caused by clinically relevant anaerobic organisms. |
format | Online Article Text |
id | pubmed-8846401 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Society for Microbiology |
record_format | MEDLINE/PubMed |
spelling | pubmed-88464012022-03-03 In Vitro Activity of Gepotidacin against Gram-Negative and Gram-Positive Anaerobes Hackel, Meredith A. Karlowsky, James A. Canino, Michele A. Sahm, Daniel F. Scangarella-Oman, Nicole E. Antimicrob Agents Chemother Susceptibility Gepotidacin (formerly GSK2140944) is a first-in-class triazaacenaphthylene antibacterial currently in phase III clinical trials. When tested against Gram-negative (n = 333) and Gram-positive (n = 225) anaerobes by agar dilution, gepotidacin inhibited 90% of isolates at concentrations of 4 and 2 μg/mL, respectively. Given gepotidacin’s in vitro activity against the anaerobic isolates tested, further study is warranted to better understand the utility of gepotidacin in the treatment of infections caused by clinically relevant anaerobic organisms. American Society for Microbiology 2022-02-15 /pmc/articles/PMC8846401/ /pubmed/34930028 http://dx.doi.org/10.1128/aac.02165-21 Text en Copyright © 2022 Hackel et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Susceptibility Hackel, Meredith A. Karlowsky, James A. Canino, Michele A. Sahm, Daniel F. Scangarella-Oman, Nicole E. In Vitro Activity of Gepotidacin against Gram-Negative and Gram-Positive Anaerobes |
title | In Vitro Activity of Gepotidacin against Gram-Negative and Gram-Positive Anaerobes |
title_full | In Vitro Activity of Gepotidacin against Gram-Negative and Gram-Positive Anaerobes |
title_fullStr | In Vitro Activity of Gepotidacin against Gram-Negative and Gram-Positive Anaerobes |
title_full_unstemmed | In Vitro Activity of Gepotidacin against Gram-Negative and Gram-Positive Anaerobes |
title_short | In Vitro Activity of Gepotidacin against Gram-Negative and Gram-Positive Anaerobes |
title_sort | in vitro activity of gepotidacin against gram-negative and gram-positive anaerobes |
topic | Susceptibility |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8846401/ https://www.ncbi.nlm.nih.gov/pubmed/34930028 http://dx.doi.org/10.1128/aac.02165-21 |
work_keys_str_mv | AT hackelmereditha invitroactivityofgepotidacinagainstgramnegativeandgrampositiveanaerobes AT karlowskyjamesa invitroactivityofgepotidacinagainstgramnegativeandgrampositiveanaerobes AT caninomichelea invitroactivityofgepotidacinagainstgramnegativeandgrampositiveanaerobes AT sahmdanielf invitroactivityofgepotidacinagainstgramnegativeandgrampositiveanaerobes AT scangarellaomannicolee invitroactivityofgepotidacinagainstgramnegativeandgrampositiveanaerobes |