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In Vitro Activity of Gepotidacin against Gram-Negative and Gram-Positive Anaerobes

Gepotidacin (formerly GSK2140944) is a first-in-class triazaacenaphthylene antibacterial currently in phase III clinical trials. When tested against Gram-negative (n = 333) and Gram-positive (n = 225) anaerobes by agar dilution, gepotidacin inhibited 90% of isolates at concentrations of 4 and 2 μg/m...

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Autores principales: Hackel, Meredith A., Karlowsky, James A., Canino, Michele A., Sahm, Daniel F., Scangarella-Oman, Nicole E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8846401/
https://www.ncbi.nlm.nih.gov/pubmed/34930028
http://dx.doi.org/10.1128/aac.02165-21
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author Hackel, Meredith A.
Karlowsky, James A.
Canino, Michele A.
Sahm, Daniel F.
Scangarella-Oman, Nicole E.
author_facet Hackel, Meredith A.
Karlowsky, James A.
Canino, Michele A.
Sahm, Daniel F.
Scangarella-Oman, Nicole E.
author_sort Hackel, Meredith A.
collection PubMed
description Gepotidacin (formerly GSK2140944) is a first-in-class triazaacenaphthylene antibacterial currently in phase III clinical trials. When tested against Gram-negative (n = 333) and Gram-positive (n = 225) anaerobes by agar dilution, gepotidacin inhibited 90% of isolates at concentrations of 4 and 2 μg/mL, respectively. Given gepotidacin’s in vitro activity against the anaerobic isolates tested, further study is warranted to better understand the utility of gepotidacin in the treatment of infections caused by clinically relevant anaerobic organisms.
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spelling pubmed-88464012022-03-03 In Vitro Activity of Gepotidacin against Gram-Negative and Gram-Positive Anaerobes Hackel, Meredith A. Karlowsky, James A. Canino, Michele A. Sahm, Daniel F. Scangarella-Oman, Nicole E. Antimicrob Agents Chemother Susceptibility Gepotidacin (formerly GSK2140944) is a first-in-class triazaacenaphthylene antibacterial currently in phase III clinical trials. When tested against Gram-negative (n = 333) and Gram-positive (n = 225) anaerobes by agar dilution, gepotidacin inhibited 90% of isolates at concentrations of 4 and 2 μg/mL, respectively. Given gepotidacin’s in vitro activity against the anaerobic isolates tested, further study is warranted to better understand the utility of gepotidacin in the treatment of infections caused by clinically relevant anaerobic organisms. American Society for Microbiology 2022-02-15 /pmc/articles/PMC8846401/ /pubmed/34930028 http://dx.doi.org/10.1128/aac.02165-21 Text en Copyright © 2022 Hackel et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Susceptibility
Hackel, Meredith A.
Karlowsky, James A.
Canino, Michele A.
Sahm, Daniel F.
Scangarella-Oman, Nicole E.
In Vitro Activity of Gepotidacin against Gram-Negative and Gram-Positive Anaerobes
title In Vitro Activity of Gepotidacin against Gram-Negative and Gram-Positive Anaerobes
title_full In Vitro Activity of Gepotidacin against Gram-Negative and Gram-Positive Anaerobes
title_fullStr In Vitro Activity of Gepotidacin against Gram-Negative and Gram-Positive Anaerobes
title_full_unstemmed In Vitro Activity of Gepotidacin against Gram-Negative and Gram-Positive Anaerobes
title_short In Vitro Activity of Gepotidacin against Gram-Negative and Gram-Positive Anaerobes
title_sort in vitro activity of gepotidacin against gram-negative and gram-positive anaerobes
topic Susceptibility
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8846401/
https://www.ncbi.nlm.nih.gov/pubmed/34930028
http://dx.doi.org/10.1128/aac.02165-21
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