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Psychosocial outcome and health behaviour intent of breast cancer patients with BRCA1/2 and PALB2 pathogenic variants unselected by a priori risk

There is an increasing number of cancer patients undertaking treatment-focused genetic testing despite not having a strong family history or high a priori risk of being carriers because of the decreasing cost of genetic testing and development of new therapies. There are limited studies on the psych...

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Autores principales: Padmanabhan, Heamanthaa, Hassan, Nur Tiara, Wong, Siu-Wan, Lee, Yong-Quan, Lim, Joanna, Hasan, Siti Norhidayu, Yip, Cheng-Har, Teo, Soo-Hwang, Thong, Meow-Keong, Mohd Taib, Nur Aishah, Yoon, Sook-Yee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8846504/
https://www.ncbi.nlm.nih.gov/pubmed/35167615
http://dx.doi.org/10.1371/journal.pone.0263675
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author Padmanabhan, Heamanthaa
Hassan, Nur Tiara
Wong, Siu-Wan
Lee, Yong-Quan
Lim, Joanna
Hasan, Siti Norhidayu
Yip, Cheng-Har
Teo, Soo-Hwang
Thong, Meow-Keong
Mohd Taib, Nur Aishah
Yoon, Sook-Yee
author_facet Padmanabhan, Heamanthaa
Hassan, Nur Tiara
Wong, Siu-Wan
Lee, Yong-Quan
Lim, Joanna
Hasan, Siti Norhidayu
Yip, Cheng-Har
Teo, Soo-Hwang
Thong, Meow-Keong
Mohd Taib, Nur Aishah
Yoon, Sook-Yee
author_sort Padmanabhan, Heamanthaa
collection PubMed
description There is an increasing number of cancer patients undertaking treatment-focused genetic testing despite not having a strong family history or high a priori risk of being carriers because of the decreasing cost of genetic testing and development of new therapies. There are limited studies on the psychosocial outcome of a positive result among breast cancer patients who are at low a priori risk, particularly in women of Asian descent. Breast cancer patients enrolled under the Malaysian Breast Cancer Genetic Study between October 2002 and February 2018 were tested for BRCA1, BRCA2 and PALB2 genes. All 104 carriers identified were invited by a research genetic counsellor for result disclosure. Of the 104 carriers, 64% (N = 66) had low a priori risk as determined by PENN II scores. Psychosocial, risk perception and health behaviour measures survey were conducted at baseline (pre-result disclosure), and at two to six weeks after result disclosure. At baseline, younger carriers with high a priori risk had higher Cancer Worry Scale scores than those with low a priori risk but all scores were within acceptable range. Around 75% and 55% of high a priori risk carriers as well as 80% and 67% of low a priori risk carriers had problems in the “living with cancer” and “children” psychosocial domains respectively. All carriers regardless of their a priori risk demonstrated an improved risk perception that also positively influenced their intent to undergo risk management procedures. This study has shown that with sufficient counselling and support, low a priori risk carriers are able to cope psychologically, have improved perceived risk and increased intent for positive health behaviour despite having less anticipation from a family history prior to knowing their germline carrier status.
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spelling pubmed-88465042022-02-16 Psychosocial outcome and health behaviour intent of breast cancer patients with BRCA1/2 and PALB2 pathogenic variants unselected by a priori risk Padmanabhan, Heamanthaa Hassan, Nur Tiara Wong, Siu-Wan Lee, Yong-Quan Lim, Joanna Hasan, Siti Norhidayu Yip, Cheng-Har Teo, Soo-Hwang Thong, Meow-Keong Mohd Taib, Nur Aishah Yoon, Sook-Yee PLoS One Research Article There is an increasing number of cancer patients undertaking treatment-focused genetic testing despite not having a strong family history or high a priori risk of being carriers because of the decreasing cost of genetic testing and development of new therapies. There are limited studies on the psychosocial outcome of a positive result among breast cancer patients who are at low a priori risk, particularly in women of Asian descent. Breast cancer patients enrolled under the Malaysian Breast Cancer Genetic Study between October 2002 and February 2018 were tested for BRCA1, BRCA2 and PALB2 genes. All 104 carriers identified were invited by a research genetic counsellor for result disclosure. Of the 104 carriers, 64% (N = 66) had low a priori risk as determined by PENN II scores. Psychosocial, risk perception and health behaviour measures survey were conducted at baseline (pre-result disclosure), and at two to six weeks after result disclosure. At baseline, younger carriers with high a priori risk had higher Cancer Worry Scale scores than those with low a priori risk but all scores were within acceptable range. Around 75% and 55% of high a priori risk carriers as well as 80% and 67% of low a priori risk carriers had problems in the “living with cancer” and “children” psychosocial domains respectively. All carriers regardless of their a priori risk demonstrated an improved risk perception that also positively influenced their intent to undergo risk management procedures. This study has shown that with sufficient counselling and support, low a priori risk carriers are able to cope psychologically, have improved perceived risk and increased intent for positive health behaviour despite having less anticipation from a family history prior to knowing their germline carrier status. Public Library of Science 2022-02-15 /pmc/articles/PMC8846504/ /pubmed/35167615 http://dx.doi.org/10.1371/journal.pone.0263675 Text en © 2022 Padmanabhan et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Padmanabhan, Heamanthaa
Hassan, Nur Tiara
Wong, Siu-Wan
Lee, Yong-Quan
Lim, Joanna
Hasan, Siti Norhidayu
Yip, Cheng-Har
Teo, Soo-Hwang
Thong, Meow-Keong
Mohd Taib, Nur Aishah
Yoon, Sook-Yee
Psychosocial outcome and health behaviour intent of breast cancer patients with BRCA1/2 and PALB2 pathogenic variants unselected by a priori risk
title Psychosocial outcome and health behaviour intent of breast cancer patients with BRCA1/2 and PALB2 pathogenic variants unselected by a priori risk
title_full Psychosocial outcome and health behaviour intent of breast cancer patients with BRCA1/2 and PALB2 pathogenic variants unselected by a priori risk
title_fullStr Psychosocial outcome and health behaviour intent of breast cancer patients with BRCA1/2 and PALB2 pathogenic variants unselected by a priori risk
title_full_unstemmed Psychosocial outcome and health behaviour intent of breast cancer patients with BRCA1/2 and PALB2 pathogenic variants unselected by a priori risk
title_short Psychosocial outcome and health behaviour intent of breast cancer patients with BRCA1/2 and PALB2 pathogenic variants unselected by a priori risk
title_sort psychosocial outcome and health behaviour intent of breast cancer patients with brca1/2 and palb2 pathogenic variants unselected by a priori risk
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8846504/
https://www.ncbi.nlm.nih.gov/pubmed/35167615
http://dx.doi.org/10.1371/journal.pone.0263675
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