Aberrant stromal tissue factor localisation and mycolactone-driven vascular dysfunction, exacerbated by IL-1β, are linked to fibrin formation in Buruli ulcer lesions

Buruli ulcer (BU) is a neglected tropical disease caused by subcutaneous infection with Mycobacterium ulcerans and its exotoxin mycolactone. BU displays coagulative necrosis and widespread fibrin deposition in affected skin tissues. Despite this, the role of the vasculature in BU pathogenesis remain...

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Detalles Bibliográficos
Autores principales: Hsieh, Louise Tzung-Harn, Dos Santos, Scott J., Hall, Belinda S., Ogbechi, Joy, Loglo, Aloysius D., Salguero, Francisco Javier, Ruf, Marie-Thérèse, Pluschke, Gerd, Simmonds, Rachel E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8846541/
https://www.ncbi.nlm.nih.gov/pubmed/35100311
http://dx.doi.org/10.1371/journal.ppat.1010280

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8846541/
https://www.ncbi.nlm.nih.gov/pubmed/35100311
http://dx.doi.org/10.1371/journal.ppat.1010280

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