4582 NICOTINAMIDE ADENINE DINUCLEOTIDE (NAD) DEPLETION MUST BE SEVERE TO INDUCE CARDIAC DYSFUNCTION AND EVENTUAL FAILURE

OBJECTIVES/GOALS: Nicotinamide adenine dinucleotide (NAD) plays essential roles in energy metabolism and cell signaling pathways. NAD functions as a coenzyme by accepting electrons during glycolysis and the TCA cycle and subsequently donates them to complex I of the electron transport chain providin...

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Detalles Bibliográficos
Autores principales: Luongo, Timothy, Wang, Lin, Chellappa, Karthikeyani, McReynolds, Melanie R., Kelly, Daniel P., Rabinowitz, Joshua D., Baur, Joseph A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2020
Materias:
Basic Science/Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8846563/
http://dx.doi.org/10.1017/cts.2020.83

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