Cargando…

Camelina sativa Oil Treatment Alleviates Castor Oil-Induced Diarrhea in ICR Mice by Regulating Intestinal Flora Composition

Diarrhea, occurring due to intestinal flora disturbance, is potentially lethal, and its current treatments have adverse effects such as constipation and vomiting. Camelina sativa oil (CSO) is a cooking ingredient and natural remedy used in several countries; however, its pharmacological effects on i...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhu, Jie, Yu, Liqin, Fan, Yi, Zhang, Huanan, Li, Feifei, Li, Xiao, Wei, Yue, Wang, Zhiyao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8846971/
https://www.ncbi.nlm.nih.gov/pubmed/35178105
http://dx.doi.org/10.1155/2022/5394514
_version_ 1784651949387284480
author Zhu, Jie
Yu, Liqin
Fan, Yi
Zhang, Huanan
Li, Feifei
Li, Xiao
Wei, Yue
Wang, Zhiyao
author_facet Zhu, Jie
Yu, Liqin
Fan, Yi
Zhang, Huanan
Li, Feifei
Li, Xiao
Wei, Yue
Wang, Zhiyao
author_sort Zhu, Jie
collection PubMed
description Diarrhea, occurring due to intestinal flora disturbance, is potentially lethal, and its current treatments have adverse effects such as constipation and vomiting. Camelina sativa oil (CSO) is a cooking ingredient and natural remedy used in several countries; however, its pharmacological effects on intestinal health remain unknown. Here, we explored the CSO treatment effects on intestinal flora in male ICR mice with castor oil-induced diarrhea. The rate and degree of loose stools, the diarrhea index, serum inflammatory indices, fecal short-chain fatty acids (SCFAs), and the diversity and abundance of intestinal flora were measured. Castor oil-administered mice experienced diarrhea, reduced intestinal flora diversity and fecal SCFAs concentrations, altered intestinal flora composition, and increased serum proinflammatory indices. In contrast, CSO treatment relieved diarrhea, improved intestinal flora composition, and increased the relative abundance of Lactobacillus and Lachnospiraceae. Additionally, CSO significantly increased the concentrations of fecal propionic acid, valeric acid, isovaleric acid, and serum sIgA, while it reduced those of serum interleukin-17. These findings suggest that CSO could be a promising preventive agent against diarrhea.
format Online
Article
Text
id pubmed-8846971
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-88469712022-02-16 Camelina sativa Oil Treatment Alleviates Castor Oil-Induced Diarrhea in ICR Mice by Regulating Intestinal Flora Composition Zhu, Jie Yu, Liqin Fan, Yi Zhang, Huanan Li, Feifei Li, Xiao Wei, Yue Wang, Zhiyao Evid Based Complement Alternat Med Research Article Diarrhea, occurring due to intestinal flora disturbance, is potentially lethal, and its current treatments have adverse effects such as constipation and vomiting. Camelina sativa oil (CSO) is a cooking ingredient and natural remedy used in several countries; however, its pharmacological effects on intestinal health remain unknown. Here, we explored the CSO treatment effects on intestinal flora in male ICR mice with castor oil-induced diarrhea. The rate and degree of loose stools, the diarrhea index, serum inflammatory indices, fecal short-chain fatty acids (SCFAs), and the diversity and abundance of intestinal flora were measured. Castor oil-administered mice experienced diarrhea, reduced intestinal flora diversity and fecal SCFAs concentrations, altered intestinal flora composition, and increased serum proinflammatory indices. In contrast, CSO treatment relieved diarrhea, improved intestinal flora composition, and increased the relative abundance of Lactobacillus and Lachnospiraceae. Additionally, CSO significantly increased the concentrations of fecal propionic acid, valeric acid, isovaleric acid, and serum sIgA, while it reduced those of serum interleukin-17. These findings suggest that CSO could be a promising preventive agent against diarrhea. Hindawi 2022-02-08 /pmc/articles/PMC8846971/ /pubmed/35178105 http://dx.doi.org/10.1155/2022/5394514 Text en Copyright © 2022 Jie Zhu et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhu, Jie
Yu, Liqin
Fan, Yi
Zhang, Huanan
Li, Feifei
Li, Xiao
Wei, Yue
Wang, Zhiyao
Camelina sativa Oil Treatment Alleviates Castor Oil-Induced Diarrhea in ICR Mice by Regulating Intestinal Flora Composition
title Camelina sativa Oil Treatment Alleviates Castor Oil-Induced Diarrhea in ICR Mice by Regulating Intestinal Flora Composition
title_full Camelina sativa Oil Treatment Alleviates Castor Oil-Induced Diarrhea in ICR Mice by Regulating Intestinal Flora Composition
title_fullStr Camelina sativa Oil Treatment Alleviates Castor Oil-Induced Diarrhea in ICR Mice by Regulating Intestinal Flora Composition
title_full_unstemmed Camelina sativa Oil Treatment Alleviates Castor Oil-Induced Diarrhea in ICR Mice by Regulating Intestinal Flora Composition
title_short Camelina sativa Oil Treatment Alleviates Castor Oil-Induced Diarrhea in ICR Mice by Regulating Intestinal Flora Composition
title_sort camelina sativa oil treatment alleviates castor oil-induced diarrhea in icr mice by regulating intestinal flora composition
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8846971/
https://www.ncbi.nlm.nih.gov/pubmed/35178105
http://dx.doi.org/10.1155/2022/5394514
work_keys_str_mv AT zhujie camelinasativaoiltreatmentalleviatescastoroilinduceddiarrheainicrmicebyregulatingintestinalfloracomposition
AT yuliqin camelinasativaoiltreatmentalleviatescastoroilinduceddiarrheainicrmicebyregulatingintestinalfloracomposition
AT fanyi camelinasativaoiltreatmentalleviatescastoroilinduceddiarrheainicrmicebyregulatingintestinalfloracomposition
AT zhanghuanan camelinasativaoiltreatmentalleviatescastoroilinduceddiarrheainicrmicebyregulatingintestinalfloracomposition
AT lifeifei camelinasativaoiltreatmentalleviatescastoroilinduceddiarrheainicrmicebyregulatingintestinalfloracomposition
AT lixiao camelinasativaoiltreatmentalleviatescastoroilinduceddiarrheainicrmicebyregulatingintestinalfloracomposition
AT weiyue camelinasativaoiltreatmentalleviatescastoroilinduceddiarrheainicrmicebyregulatingintestinalfloracomposition
AT wangzhiyao camelinasativaoiltreatmentalleviatescastoroilinduceddiarrheainicrmicebyregulatingintestinalfloracomposition