Cargando…
Ferroptosis in Rheumatoid Arthritis: A Potential Therapeutic Strategy
Ferroptosis is one of the newly discovered forms of cell-regulated death characterized by iron-dependent lipid peroxidation. Extensive research has focused on the roles of ferroptosis in tumors, blood diseases, and neurological diseases. Some recent findings have indicated that ferroptosis may also...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847160/ https://www.ncbi.nlm.nih.gov/pubmed/35185879 http://dx.doi.org/10.3389/fimmu.2022.779585 |
_version_ | 1784651991315644416 |
---|---|
author | Zhao, Ting Yang, Qi Xi, Yujiang Xie, Zhaohu Shen, Jiayan Li, Zhenmin Li, Zhaofu Qin, Dongdong |
author_facet | Zhao, Ting Yang, Qi Xi, Yujiang Xie, Zhaohu Shen, Jiayan Li, Zhenmin Li, Zhaofu Qin, Dongdong |
author_sort | Zhao, Ting |
collection | PubMed |
description | Ferroptosis is one of the newly discovered forms of cell-regulated death characterized by iron-dependent lipid peroxidation. Extensive research has focused on the roles of ferroptosis in tumors, blood diseases, and neurological diseases. Some recent findings have indicated that ferroptosis may also be related to the occurrence and development of inflammatory arthritis. Ferroptosis may be a potential therapeutic target, and few studies in vitro and animal models have shown implications in the pathogenesis of inflammatory arthritis. This mini review discussed the common features between ferroptosis and the pathogenesis of rheumatoid arthritis (RA), and evaluated therapeutic applications of ferroptosis regulators in preclinical and clinical research. Some critical issues worth paying attention to were also raised to guide future research efforts. |
format | Online Article Text |
id | pubmed-8847160 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88471602022-02-17 Ferroptosis in Rheumatoid Arthritis: A Potential Therapeutic Strategy Zhao, Ting Yang, Qi Xi, Yujiang Xie, Zhaohu Shen, Jiayan Li, Zhenmin Li, Zhaofu Qin, Dongdong Front Immunol Immunology Ferroptosis is one of the newly discovered forms of cell-regulated death characterized by iron-dependent lipid peroxidation. Extensive research has focused on the roles of ferroptosis in tumors, blood diseases, and neurological diseases. Some recent findings have indicated that ferroptosis may also be related to the occurrence and development of inflammatory arthritis. Ferroptosis may be a potential therapeutic target, and few studies in vitro and animal models have shown implications in the pathogenesis of inflammatory arthritis. This mini review discussed the common features between ferroptosis and the pathogenesis of rheumatoid arthritis (RA), and evaluated therapeutic applications of ferroptosis regulators in preclinical and clinical research. Some critical issues worth paying attention to were also raised to guide future research efforts. Frontiers Media S.A. 2022-02-02 /pmc/articles/PMC8847160/ /pubmed/35185879 http://dx.doi.org/10.3389/fimmu.2022.779585 Text en Copyright © 2022 Zhao, Yang, Xi, Xie, Shen, Li, Li and Qin https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Zhao, Ting Yang, Qi Xi, Yujiang Xie, Zhaohu Shen, Jiayan Li, Zhenmin Li, Zhaofu Qin, Dongdong Ferroptosis in Rheumatoid Arthritis: A Potential Therapeutic Strategy |
title | Ferroptosis in Rheumatoid Arthritis: A Potential Therapeutic Strategy |
title_full | Ferroptosis in Rheumatoid Arthritis: A Potential Therapeutic Strategy |
title_fullStr | Ferroptosis in Rheumatoid Arthritis: A Potential Therapeutic Strategy |
title_full_unstemmed | Ferroptosis in Rheumatoid Arthritis: A Potential Therapeutic Strategy |
title_short | Ferroptosis in Rheumatoid Arthritis: A Potential Therapeutic Strategy |
title_sort | ferroptosis in rheumatoid arthritis: a potential therapeutic strategy |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847160/ https://www.ncbi.nlm.nih.gov/pubmed/35185879 http://dx.doi.org/10.3389/fimmu.2022.779585 |
work_keys_str_mv | AT zhaoting ferroptosisinrheumatoidarthritisapotentialtherapeuticstrategy AT yangqi ferroptosisinrheumatoidarthritisapotentialtherapeuticstrategy AT xiyujiang ferroptosisinrheumatoidarthritisapotentialtherapeuticstrategy AT xiezhaohu ferroptosisinrheumatoidarthritisapotentialtherapeuticstrategy AT shenjiayan ferroptosisinrheumatoidarthritisapotentialtherapeuticstrategy AT lizhenmin ferroptosisinrheumatoidarthritisapotentialtherapeuticstrategy AT lizhaofu ferroptosisinrheumatoidarthritisapotentialtherapeuticstrategy AT qindongdong ferroptosisinrheumatoidarthritisapotentialtherapeuticstrategy |