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Ferroptosis in Rheumatoid Arthritis: A Potential Therapeutic Strategy

Ferroptosis is one of the newly discovered forms of cell-regulated death characterized by iron-dependent lipid peroxidation. Extensive research has focused on the roles of ferroptosis in tumors, blood diseases, and neurological diseases. Some recent findings have indicated that ferroptosis may also...

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Autores principales: Zhao, Ting, Yang, Qi, Xi, Yujiang, Xie, Zhaohu, Shen, Jiayan, Li, Zhenmin, Li, Zhaofu, Qin, Dongdong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847160/
https://www.ncbi.nlm.nih.gov/pubmed/35185879
http://dx.doi.org/10.3389/fimmu.2022.779585
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author Zhao, Ting
Yang, Qi
Xi, Yujiang
Xie, Zhaohu
Shen, Jiayan
Li, Zhenmin
Li, Zhaofu
Qin, Dongdong
author_facet Zhao, Ting
Yang, Qi
Xi, Yujiang
Xie, Zhaohu
Shen, Jiayan
Li, Zhenmin
Li, Zhaofu
Qin, Dongdong
author_sort Zhao, Ting
collection PubMed
description Ferroptosis is one of the newly discovered forms of cell-regulated death characterized by iron-dependent lipid peroxidation. Extensive research has focused on the roles of ferroptosis in tumors, blood diseases, and neurological diseases. Some recent findings have indicated that ferroptosis may also be related to the occurrence and development of inflammatory arthritis. Ferroptosis may be a potential therapeutic target, and few studies in vitro and animal models have shown implications in the pathogenesis of inflammatory arthritis. This mini review discussed the common features between ferroptosis and the pathogenesis of rheumatoid arthritis (RA), and evaluated therapeutic applications of ferroptosis regulators in preclinical and clinical research. Some critical issues worth paying attention to were also raised to guide future research efforts.
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spelling pubmed-88471602022-02-17 Ferroptosis in Rheumatoid Arthritis: A Potential Therapeutic Strategy Zhao, Ting Yang, Qi Xi, Yujiang Xie, Zhaohu Shen, Jiayan Li, Zhenmin Li, Zhaofu Qin, Dongdong Front Immunol Immunology Ferroptosis is one of the newly discovered forms of cell-regulated death characterized by iron-dependent lipid peroxidation. Extensive research has focused on the roles of ferroptosis in tumors, blood diseases, and neurological diseases. Some recent findings have indicated that ferroptosis may also be related to the occurrence and development of inflammatory arthritis. Ferroptosis may be a potential therapeutic target, and few studies in vitro and animal models have shown implications in the pathogenesis of inflammatory arthritis. This mini review discussed the common features between ferroptosis and the pathogenesis of rheumatoid arthritis (RA), and evaluated therapeutic applications of ferroptosis regulators in preclinical and clinical research. Some critical issues worth paying attention to were also raised to guide future research efforts. Frontiers Media S.A. 2022-02-02 /pmc/articles/PMC8847160/ /pubmed/35185879 http://dx.doi.org/10.3389/fimmu.2022.779585 Text en Copyright © 2022 Zhao, Yang, Xi, Xie, Shen, Li, Li and Qin https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zhao, Ting
Yang, Qi
Xi, Yujiang
Xie, Zhaohu
Shen, Jiayan
Li, Zhenmin
Li, Zhaofu
Qin, Dongdong
Ferroptosis in Rheumatoid Arthritis: A Potential Therapeutic Strategy
title Ferroptosis in Rheumatoid Arthritis: A Potential Therapeutic Strategy
title_full Ferroptosis in Rheumatoid Arthritis: A Potential Therapeutic Strategy
title_fullStr Ferroptosis in Rheumatoid Arthritis: A Potential Therapeutic Strategy
title_full_unstemmed Ferroptosis in Rheumatoid Arthritis: A Potential Therapeutic Strategy
title_short Ferroptosis in Rheumatoid Arthritis: A Potential Therapeutic Strategy
title_sort ferroptosis in rheumatoid arthritis: a potential therapeutic strategy
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847160/
https://www.ncbi.nlm.nih.gov/pubmed/35185879
http://dx.doi.org/10.3389/fimmu.2022.779585
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