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Non-Coding RNAs in Colorectal Cancer: Their Functions and Mechanisms

Colorectal cancer (CRC) is a common malignancy with high mortality. However, the molecular mechanisms underlying CRC remain unclear. Controversies over the exact functions of non-coding RNAs (ncRNAs) in the progression of CRC have been prevailing for multiple years. Recently, accumulating evidence h...

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Detalles Bibliográficos
Autores principales: Jia, Zimo, An, Jiaqi, Liu, Ziyuan, Zhang, Fan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847166/
https://www.ncbi.nlm.nih.gov/pubmed/35186731
http://dx.doi.org/10.3389/fonc.2022.783079
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author Jia, Zimo
An, Jiaqi
Liu, Ziyuan
Zhang, Fan
author_facet Jia, Zimo
An, Jiaqi
Liu, Ziyuan
Zhang, Fan
author_sort Jia, Zimo
collection PubMed
description Colorectal cancer (CRC) is a common malignancy with high mortality. However, the molecular mechanisms underlying CRC remain unclear. Controversies over the exact functions of non-coding RNAs (ncRNAs) in the progression of CRC have been prevailing for multiple years. Recently, accumulating evidence has demonstrated the regulatory roles of ncRNAs in various human cancers, including CRC. The intracellular signaling pathways by which ncRNAs act on tumor cells have been explored, and in CRC, various studies have identified numerous dysregulated ncRNAs that serve as oncogenes or tumor suppressors in the process of tumorigenesis through diverse mechanisms. In this review, we have summarized the functions and mechanisms of ncRNAs (mainly lncRNAs, miRNAs, and circRNAs) in the tumorigenesis of CRC. We also discuss the potential applications of ncRNAs as diagnostic and prognostic tools, as well as therapeutic targets in CRC. This review details strategies that trigger the recognition of CRC-related ncRNAs, as well as the methodologies and challenges of studying these molecules, and the forthcoming clinical applications of these findings.
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spelling pubmed-88471662022-02-17 Non-Coding RNAs in Colorectal Cancer: Their Functions and Mechanisms Jia, Zimo An, Jiaqi Liu, Ziyuan Zhang, Fan Front Oncol Oncology Colorectal cancer (CRC) is a common malignancy with high mortality. However, the molecular mechanisms underlying CRC remain unclear. Controversies over the exact functions of non-coding RNAs (ncRNAs) in the progression of CRC have been prevailing for multiple years. Recently, accumulating evidence has demonstrated the regulatory roles of ncRNAs in various human cancers, including CRC. The intracellular signaling pathways by which ncRNAs act on tumor cells have been explored, and in CRC, various studies have identified numerous dysregulated ncRNAs that serve as oncogenes or tumor suppressors in the process of tumorigenesis through diverse mechanisms. In this review, we have summarized the functions and mechanisms of ncRNAs (mainly lncRNAs, miRNAs, and circRNAs) in the tumorigenesis of CRC. We also discuss the potential applications of ncRNAs as diagnostic and prognostic tools, as well as therapeutic targets in CRC. This review details strategies that trigger the recognition of CRC-related ncRNAs, as well as the methodologies and challenges of studying these molecules, and the forthcoming clinical applications of these findings. Frontiers Media S.A. 2022-02-02 /pmc/articles/PMC8847166/ /pubmed/35186731 http://dx.doi.org/10.3389/fonc.2022.783079 Text en Copyright © 2022 Jia, An, Liu and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Jia, Zimo
An, Jiaqi
Liu, Ziyuan
Zhang, Fan
Non-Coding RNAs in Colorectal Cancer: Their Functions and Mechanisms
title Non-Coding RNAs in Colorectal Cancer: Their Functions and Mechanisms
title_full Non-Coding RNAs in Colorectal Cancer: Their Functions and Mechanisms
title_fullStr Non-Coding RNAs in Colorectal Cancer: Their Functions and Mechanisms
title_full_unstemmed Non-Coding RNAs in Colorectal Cancer: Their Functions and Mechanisms
title_short Non-Coding RNAs in Colorectal Cancer: Their Functions and Mechanisms
title_sort non-coding rnas in colorectal cancer: their functions and mechanisms
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847166/
https://www.ncbi.nlm.nih.gov/pubmed/35186731
http://dx.doi.org/10.3389/fonc.2022.783079
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