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Case Series: Acute Hemorrhagic Encephalomyelitis After SARS-CoV-2 Vaccination

We present three cases fulfilling diagnostic criteria of hemorrhagic variants of acute disseminated encephalomyelitis (acute hemorrhagic encephalomyelitis, AHEM) occurring within 9 days after the first shot of ChAdOx1 nCoV-19. AHEM was diagnosed using magnetic resonance imaging, cerebrospinal fluid...

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Autores principales: Ancau, Mihai, Liesche-Starnecker, Friederike, Niederschweiberer, Johanna, Krieg, Sandro M., Zimmer, Claus, Lingg, Charlotte, Kumpfmüller, Daniela, Ikenberg, Benno, Ploner, Markus, Hemmer, Bernhard, Wunderlich, Silke, Mühlau, Mark, Knier, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847228/
https://www.ncbi.nlm.nih.gov/pubmed/35185757
http://dx.doi.org/10.3389/fneur.2021.820049
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author Ancau, Mihai
Liesche-Starnecker, Friederike
Niederschweiberer, Johanna
Krieg, Sandro M.
Zimmer, Claus
Lingg, Charlotte
Kumpfmüller, Daniela
Ikenberg, Benno
Ploner, Markus
Hemmer, Bernhard
Wunderlich, Silke
Mühlau, Mark
Knier, Benjamin
author_facet Ancau, Mihai
Liesche-Starnecker, Friederike
Niederschweiberer, Johanna
Krieg, Sandro M.
Zimmer, Claus
Lingg, Charlotte
Kumpfmüller, Daniela
Ikenberg, Benno
Ploner, Markus
Hemmer, Bernhard
Wunderlich, Silke
Mühlau, Mark
Knier, Benjamin
author_sort Ancau, Mihai
collection PubMed
description We present three cases fulfilling diagnostic criteria of hemorrhagic variants of acute disseminated encephalomyelitis (acute hemorrhagic encephalomyelitis, AHEM) occurring within 9 days after the first shot of ChAdOx1 nCoV-19. AHEM was diagnosed using magnetic resonance imaging, cerebrospinal fluid analysis and brain biopsy in one case. The close temporal association with the vaccination, the immune-related nature of the disease as well as the lack of other canonical precipitating factors suggested that AHEM was a vaccine-related adverse effect. We believe that AHEM might reflect a novel COVID-19 vaccine-related adverse event for which physicians should be vigilant and sensitized.
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spelling pubmed-88472282022-02-17 Case Series: Acute Hemorrhagic Encephalomyelitis After SARS-CoV-2 Vaccination Ancau, Mihai Liesche-Starnecker, Friederike Niederschweiberer, Johanna Krieg, Sandro M. Zimmer, Claus Lingg, Charlotte Kumpfmüller, Daniela Ikenberg, Benno Ploner, Markus Hemmer, Bernhard Wunderlich, Silke Mühlau, Mark Knier, Benjamin Front Neurol Neurology We present three cases fulfilling diagnostic criteria of hemorrhagic variants of acute disseminated encephalomyelitis (acute hemorrhagic encephalomyelitis, AHEM) occurring within 9 days after the first shot of ChAdOx1 nCoV-19. AHEM was diagnosed using magnetic resonance imaging, cerebrospinal fluid analysis and brain biopsy in one case. The close temporal association with the vaccination, the immune-related nature of the disease as well as the lack of other canonical precipitating factors suggested that AHEM was a vaccine-related adverse effect. We believe that AHEM might reflect a novel COVID-19 vaccine-related adverse event for which physicians should be vigilant and sensitized. Frontiers Media S.A. 2022-02-02 /pmc/articles/PMC8847228/ /pubmed/35185757 http://dx.doi.org/10.3389/fneur.2021.820049 Text en Copyright © 2022 Ancau, Liesche-Starnecker, Niederschweiberer, Krieg, Zimmer, Lingg, Kumpfmüller, Ikenberg, Ploner, Hemmer, Wunderlich, Mühlau and Knier. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Ancau, Mihai
Liesche-Starnecker, Friederike
Niederschweiberer, Johanna
Krieg, Sandro M.
Zimmer, Claus
Lingg, Charlotte
Kumpfmüller, Daniela
Ikenberg, Benno
Ploner, Markus
Hemmer, Bernhard
Wunderlich, Silke
Mühlau, Mark
Knier, Benjamin
Case Series: Acute Hemorrhagic Encephalomyelitis After SARS-CoV-2 Vaccination
title Case Series: Acute Hemorrhagic Encephalomyelitis After SARS-CoV-2 Vaccination
title_full Case Series: Acute Hemorrhagic Encephalomyelitis After SARS-CoV-2 Vaccination
title_fullStr Case Series: Acute Hemorrhagic Encephalomyelitis After SARS-CoV-2 Vaccination
title_full_unstemmed Case Series: Acute Hemorrhagic Encephalomyelitis After SARS-CoV-2 Vaccination
title_short Case Series: Acute Hemorrhagic Encephalomyelitis After SARS-CoV-2 Vaccination
title_sort case series: acute hemorrhagic encephalomyelitis after sars-cov-2 vaccination
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847228/
https://www.ncbi.nlm.nih.gov/pubmed/35185757
http://dx.doi.org/10.3389/fneur.2021.820049
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