Cargando…
Case Series: Acute Hemorrhagic Encephalomyelitis After SARS-CoV-2 Vaccination
We present three cases fulfilling diagnostic criteria of hemorrhagic variants of acute disseminated encephalomyelitis (acute hemorrhagic encephalomyelitis, AHEM) occurring within 9 days after the first shot of ChAdOx1 nCoV-19. AHEM was diagnosed using magnetic resonance imaging, cerebrospinal fluid...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847228/ https://www.ncbi.nlm.nih.gov/pubmed/35185757 http://dx.doi.org/10.3389/fneur.2021.820049 |
_version_ | 1784652008590934016 |
---|---|
author | Ancau, Mihai Liesche-Starnecker, Friederike Niederschweiberer, Johanna Krieg, Sandro M. Zimmer, Claus Lingg, Charlotte Kumpfmüller, Daniela Ikenberg, Benno Ploner, Markus Hemmer, Bernhard Wunderlich, Silke Mühlau, Mark Knier, Benjamin |
author_facet | Ancau, Mihai Liesche-Starnecker, Friederike Niederschweiberer, Johanna Krieg, Sandro M. Zimmer, Claus Lingg, Charlotte Kumpfmüller, Daniela Ikenberg, Benno Ploner, Markus Hemmer, Bernhard Wunderlich, Silke Mühlau, Mark Knier, Benjamin |
author_sort | Ancau, Mihai |
collection | PubMed |
description | We present three cases fulfilling diagnostic criteria of hemorrhagic variants of acute disseminated encephalomyelitis (acute hemorrhagic encephalomyelitis, AHEM) occurring within 9 days after the first shot of ChAdOx1 nCoV-19. AHEM was diagnosed using magnetic resonance imaging, cerebrospinal fluid analysis and brain biopsy in one case. The close temporal association with the vaccination, the immune-related nature of the disease as well as the lack of other canonical precipitating factors suggested that AHEM was a vaccine-related adverse effect. We believe that AHEM might reflect a novel COVID-19 vaccine-related adverse event for which physicians should be vigilant and sensitized. |
format | Online Article Text |
id | pubmed-8847228 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88472282022-02-17 Case Series: Acute Hemorrhagic Encephalomyelitis After SARS-CoV-2 Vaccination Ancau, Mihai Liesche-Starnecker, Friederike Niederschweiberer, Johanna Krieg, Sandro M. Zimmer, Claus Lingg, Charlotte Kumpfmüller, Daniela Ikenberg, Benno Ploner, Markus Hemmer, Bernhard Wunderlich, Silke Mühlau, Mark Knier, Benjamin Front Neurol Neurology We present three cases fulfilling diagnostic criteria of hemorrhagic variants of acute disseminated encephalomyelitis (acute hemorrhagic encephalomyelitis, AHEM) occurring within 9 days after the first shot of ChAdOx1 nCoV-19. AHEM was diagnosed using magnetic resonance imaging, cerebrospinal fluid analysis and brain biopsy in one case. The close temporal association with the vaccination, the immune-related nature of the disease as well as the lack of other canonical precipitating factors suggested that AHEM was a vaccine-related adverse effect. We believe that AHEM might reflect a novel COVID-19 vaccine-related adverse event for which physicians should be vigilant and sensitized. Frontiers Media S.A. 2022-02-02 /pmc/articles/PMC8847228/ /pubmed/35185757 http://dx.doi.org/10.3389/fneur.2021.820049 Text en Copyright © 2022 Ancau, Liesche-Starnecker, Niederschweiberer, Krieg, Zimmer, Lingg, Kumpfmüller, Ikenberg, Ploner, Hemmer, Wunderlich, Mühlau and Knier. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Ancau, Mihai Liesche-Starnecker, Friederike Niederschweiberer, Johanna Krieg, Sandro M. Zimmer, Claus Lingg, Charlotte Kumpfmüller, Daniela Ikenberg, Benno Ploner, Markus Hemmer, Bernhard Wunderlich, Silke Mühlau, Mark Knier, Benjamin Case Series: Acute Hemorrhagic Encephalomyelitis After SARS-CoV-2 Vaccination |
title | Case Series: Acute Hemorrhagic Encephalomyelitis After SARS-CoV-2 Vaccination |
title_full | Case Series: Acute Hemorrhagic Encephalomyelitis After SARS-CoV-2 Vaccination |
title_fullStr | Case Series: Acute Hemorrhagic Encephalomyelitis After SARS-CoV-2 Vaccination |
title_full_unstemmed | Case Series: Acute Hemorrhagic Encephalomyelitis After SARS-CoV-2 Vaccination |
title_short | Case Series: Acute Hemorrhagic Encephalomyelitis After SARS-CoV-2 Vaccination |
title_sort | case series: acute hemorrhagic encephalomyelitis after sars-cov-2 vaccination |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847228/ https://www.ncbi.nlm.nih.gov/pubmed/35185757 http://dx.doi.org/10.3389/fneur.2021.820049 |
work_keys_str_mv | AT ancaumihai caseseriesacutehemorrhagicencephalomyelitisaftersarscov2vaccination AT lieschestarneckerfriederike caseseriesacutehemorrhagicencephalomyelitisaftersarscov2vaccination AT niederschweibererjohanna caseseriesacutehemorrhagicencephalomyelitisaftersarscov2vaccination AT kriegsandrom caseseriesacutehemorrhagicencephalomyelitisaftersarscov2vaccination AT zimmerclaus caseseriesacutehemorrhagicencephalomyelitisaftersarscov2vaccination AT linggcharlotte caseseriesacutehemorrhagicencephalomyelitisaftersarscov2vaccination AT kumpfmullerdaniela caseseriesacutehemorrhagicencephalomyelitisaftersarscov2vaccination AT ikenbergbenno caseseriesacutehemorrhagicencephalomyelitisaftersarscov2vaccination AT plonermarkus caseseriesacutehemorrhagicencephalomyelitisaftersarscov2vaccination AT hemmerbernhard caseseriesacutehemorrhagicencephalomyelitisaftersarscov2vaccination AT wunderlichsilke caseseriesacutehemorrhagicencephalomyelitisaftersarscov2vaccination AT muhlaumark caseseriesacutehemorrhagicencephalomyelitisaftersarscov2vaccination AT knierbenjamin caseseriesacutehemorrhagicencephalomyelitisaftersarscov2vaccination |