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The emergence of the postgenomic gene

The identity and the existence of genes has been challenged by postgenomic discoveries. Specifically, the consideration of molecular and cellular phenomena in which genes are embedded has proved relevant for their understanding. In response to these challenges, I will argue that the complexity of ge...

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Autor principal: Bellazzi, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847258/
https://www.ncbi.nlm.nih.gov/pubmed/35222747
http://dx.doi.org/10.1007/s13194-022-00446-0
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author Bellazzi, Francesca
author_facet Bellazzi, Francesca
author_sort Bellazzi, Francesca
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description The identity and the existence of genes has been challenged by postgenomic discoveries. Specifically, the consideration of molecular and cellular phenomena in which genes are embedded has proved relevant for their understanding. In response to these challenges, I will argue that the complexity of genetic phenomena supports the weak emergence of genes from the DNA. In Section 2, I will expose what genes are taken to be in the postgenomic world. In Section 3, I will present the relevant account of emergence. I consider weak emergence as in Franklin and Knox (Studies for the History and Philosophy of Modern Physics, 64, 68–78, 2018), for which a phenomenon is emergent when it displays novelty and robustness. In Section 4, I will argue that genes are weakly emergent since they are novel, improving explanations, and robust in respect to some perturbations. Then, I will conclude in Section 5 that genes’ emergence is a way to allow genes’ flexibility and context dependency, without compromising their existence.
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spelling pubmed-88472582022-02-23 The emergence of the postgenomic gene Bellazzi, Francesca Eur J Philos Sci Paper in the Philosophy of the Life Sciences The identity and the existence of genes has been challenged by postgenomic discoveries. Specifically, the consideration of molecular and cellular phenomena in which genes are embedded has proved relevant for their understanding. In response to these challenges, I will argue that the complexity of genetic phenomena supports the weak emergence of genes from the DNA. In Section 2, I will expose what genes are taken to be in the postgenomic world. In Section 3, I will present the relevant account of emergence. I consider weak emergence as in Franklin and Knox (Studies for the History and Philosophy of Modern Physics, 64, 68–78, 2018), for which a phenomenon is emergent when it displays novelty and robustness. In Section 4, I will argue that genes are weakly emergent since they are novel, improving explanations, and robust in respect to some perturbations. Then, I will conclude in Section 5 that genes’ emergence is a way to allow genes’ flexibility and context dependency, without compromising their existence. Springer Netherlands 2022-02-15 2022 /pmc/articles/PMC8847258/ /pubmed/35222747 http://dx.doi.org/10.1007/s13194-022-00446-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Paper in the Philosophy of the Life Sciences
Bellazzi, Francesca
The emergence of the postgenomic gene
title The emergence of the postgenomic gene
title_full The emergence of the postgenomic gene
title_fullStr The emergence of the postgenomic gene
title_full_unstemmed The emergence of the postgenomic gene
title_short The emergence of the postgenomic gene
title_sort emergence of the postgenomic gene
topic Paper in the Philosophy of the Life Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847258/
https://www.ncbi.nlm.nih.gov/pubmed/35222747
http://dx.doi.org/10.1007/s13194-022-00446-0
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