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Targeting ApoC3 Paradoxically Aggravates Atherosclerosis in Hamsters With Severe Refractory Hypercholesterolemia

RATIONALE: ApoC3 plays a central role in the hydrolysis process of triglyceride (TG)-rich lipoproteins mediated by lipoprotein lipase (LPL), which levels are positively associated with the incidence of cardiovascular disease (CVD). Although targeting ApoC3 by antisense oligonucleotide (ASO), Volanes...

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Detalles Bibliográficos
Autores principales:	Xu, Yitong, Guo, Jiabao, Zhang, Ling, Miao, Guolin, Lai, Pingping, Zhang, Wenxi, Liu, Lili, Hou, Xinlin, Wang, Yuhui, Huang, Wei, Liu, George, Gao, Mingming, Xian, Xunde
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cardiovascular Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847384/ https://www.ncbi.nlm.nih.gov/pubmed/35187136 http://dx.doi.org/10.3389/fcvm.2022.840358

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