Re-engineered BCG overexpressing cyclic di-AMP augments trained immunity and exhibits improved efficacy against bladder cancer

In addition to its role as a TB vaccine, BCG has been shown to elicit heterologous protection against many other pathogens including viruses through a process termed trained immunity. Despite its potential as a broadly protective vaccine, little has been done to determine if BCG-mediated trained imm...

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Detalles Bibliográficos
Autores principales: Singh, Alok Kumar, Praharaj, Monali, Lombardo, Kara A., Yoshida, Takahiro, Matoso, Andres, Baras, Alex S., Zhao, Liang, Srikrishna, Geetha, Huang, Joy, Prasad, Pankaj, Powell, Jonathan D., Kates, Max, McConkey, David, Pardoll, Drew M., Bishai, William R., Bivalacqua, Trinity J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847416/
https://www.ncbi.nlm.nih.gov/pubmed/35169141
http://dx.doi.org/10.1038/s41467-022-28509-z

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