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Oscillatory Behaviors of microRNA Networks: Emerging Roles in Retinal Development
A broad repertoire of transcription factors and other genes display oscillatory patterns of expression, typically ranging from 30 min to 24 h. These oscillations are associated with a variety of biological processes, including the circadian cycle, somite segmentation, cell cycle, and metabolism. The...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847441/ https://www.ncbi.nlm.nih.gov/pubmed/35186936 http://dx.doi.org/10.3389/fcell.2022.831750 |
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author | Fishman, Elizabeth S. Han, Jisoo S. La Torre, Anna |
author_facet | Fishman, Elizabeth S. Han, Jisoo S. La Torre, Anna |
author_sort | Fishman, Elizabeth S. |
collection | PubMed |
description | A broad repertoire of transcription factors and other genes display oscillatory patterns of expression, typically ranging from 30 min to 24 h. These oscillations are associated with a variety of biological processes, including the circadian cycle, somite segmentation, cell cycle, and metabolism. These rhythmic behaviors are often prompted by transcriptional feedback loops in which transcriptional activities are inhibited by their corresponding gene target products. Oscillatory transcriptional patterns have been proposed as a mechanism to drive biological clocks, the molecular machinery that transforms temporal information into accurate spatial patterning during development. Notably, several microRNAs (miRNAs) -small non-coding RNA molecules-have been recently shown to both exhibit rhythmic expression patterns and regulate oscillatory activities. Here, we discuss some of these new findings in the context of the developing retina. We propose that miRNA oscillations are a powerful mechanism to coordinate signaling pathways and gene expression, and that addressing the dynamic interplay between miRNA expression and their target genes could be key for a more complete understanding of many developmental processes. |
format | Online Article Text |
id | pubmed-8847441 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88474412022-02-17 Oscillatory Behaviors of microRNA Networks: Emerging Roles in Retinal Development Fishman, Elizabeth S. Han, Jisoo S. La Torre, Anna Front Cell Dev Biol Cell and Developmental Biology A broad repertoire of transcription factors and other genes display oscillatory patterns of expression, typically ranging from 30 min to 24 h. These oscillations are associated with a variety of biological processes, including the circadian cycle, somite segmentation, cell cycle, and metabolism. These rhythmic behaviors are often prompted by transcriptional feedback loops in which transcriptional activities are inhibited by their corresponding gene target products. Oscillatory transcriptional patterns have been proposed as a mechanism to drive biological clocks, the molecular machinery that transforms temporal information into accurate spatial patterning during development. Notably, several microRNAs (miRNAs) -small non-coding RNA molecules-have been recently shown to both exhibit rhythmic expression patterns and regulate oscillatory activities. Here, we discuss some of these new findings in the context of the developing retina. We propose that miRNA oscillations are a powerful mechanism to coordinate signaling pathways and gene expression, and that addressing the dynamic interplay between miRNA expression and their target genes could be key for a more complete understanding of many developmental processes. Frontiers Media S.A. 2022-02-02 /pmc/articles/PMC8847441/ /pubmed/35186936 http://dx.doi.org/10.3389/fcell.2022.831750 Text en Copyright © 2022 Fishman, Han and La Torre. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Fishman, Elizabeth S. Han, Jisoo S. La Torre, Anna Oscillatory Behaviors of microRNA Networks: Emerging Roles in Retinal Development |
title | Oscillatory Behaviors of microRNA Networks: Emerging Roles in Retinal Development |
title_full | Oscillatory Behaviors of microRNA Networks: Emerging Roles in Retinal Development |
title_fullStr | Oscillatory Behaviors of microRNA Networks: Emerging Roles in Retinal Development |
title_full_unstemmed | Oscillatory Behaviors of microRNA Networks: Emerging Roles in Retinal Development |
title_short | Oscillatory Behaviors of microRNA Networks: Emerging Roles in Retinal Development |
title_sort | oscillatory behaviors of microrna networks: emerging roles in retinal development |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847441/ https://www.ncbi.nlm.nih.gov/pubmed/35186936 http://dx.doi.org/10.3389/fcell.2022.831750 |
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