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Awareness and Epidemiology of Chronic Hepatitis C Virus Infections in Florida

INTRODUCTION: Progress towards achieving hepatitis C virus (HCV) elimination in Florida has been hampered by barriers to screening, linkage to care, and treatment. This study aims to describe the HCV care cascade and patient characteristics in Florida. METHODS: This analysis combined HCV-related lab...

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Autores principales: Thomas, Emmanuel, Cheng, Wei-Han, Dylla, Douglas E., Marx, Steven E., Carabino, Jana, Xu, Qingqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847470/
https://www.ncbi.nlm.nih.gov/pubmed/34914078
http://dx.doi.org/10.1007/s40121-021-00578-5
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author Thomas, Emmanuel
Cheng, Wei-Han
Dylla, Douglas E.
Marx, Steven E.
Carabino, Jana
Xu, Qingqing
author_facet Thomas, Emmanuel
Cheng, Wei-Han
Dylla, Douglas E.
Marx, Steven E.
Carabino, Jana
Xu, Qingqing
author_sort Thomas, Emmanuel
collection PubMed
description INTRODUCTION: Progress towards achieving hepatitis C virus (HCV) elimination in Florida has been hampered by barriers to screening, linkage to care, and treatment. This study aims to describe the HCV care cascade and patient characteristics in Florida. METHODS: This analysis combined HCV-related laboratory data and patient characteristics from two, large US laboratory datasets that included individuals tested for HCV antibody (Ab) and HCV ribonucleic acid (RNA) viral load between January 2015 and December 2019. A decline in sequential HCV RNA viral loads was used to impute HCV treatment. Machine-learning algorithms were used to identify cured patients. The actual number of individuals with HCV Ab screening, and the number and percentage of persons who were HCV RNA-positive and treated, were calculated. RESULTS: The number of persons in Florida diagnosed as HCV RNA-positive was 31,659 in 2019. The number of individuals HCV Ab screened in 2019 was 1,024,379, an increase of 82.5% from 2015. The percentage of HCV Ab-positive individuals was 4.1%, demonstrating a 16.2% decrease from 2015. The percentage of HCV RNA-positive patients who were treated was 27.0%, a 10.5% decrease from 2015 to 2019. CONCLUSION: An Ab positivity rate > 4-times higher than national estimates with increased screening among baby boomers, but decreased screening among younger individuals, suggests risk-based screening is still common practice in Florida, despite universal screening recommendations. Public health efforts to decrease barriers to screening, linkage to care, and treatment are needed to reduce the burden of HCV in Florida and to ensure progress toward virus elimination.
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spelling pubmed-88474702022-02-23 Awareness and Epidemiology of Chronic Hepatitis C Virus Infections in Florida Thomas, Emmanuel Cheng, Wei-Han Dylla, Douglas E. Marx, Steven E. Carabino, Jana Xu, Qingqing Infect Dis Ther Original Research INTRODUCTION: Progress towards achieving hepatitis C virus (HCV) elimination in Florida has been hampered by barriers to screening, linkage to care, and treatment. This study aims to describe the HCV care cascade and patient characteristics in Florida. METHODS: This analysis combined HCV-related laboratory data and patient characteristics from two, large US laboratory datasets that included individuals tested for HCV antibody (Ab) and HCV ribonucleic acid (RNA) viral load between January 2015 and December 2019. A decline in sequential HCV RNA viral loads was used to impute HCV treatment. Machine-learning algorithms were used to identify cured patients. The actual number of individuals with HCV Ab screening, and the number and percentage of persons who were HCV RNA-positive and treated, were calculated. RESULTS: The number of persons in Florida diagnosed as HCV RNA-positive was 31,659 in 2019. The number of individuals HCV Ab screened in 2019 was 1,024,379, an increase of 82.5% from 2015. The percentage of HCV Ab-positive individuals was 4.1%, demonstrating a 16.2% decrease from 2015. The percentage of HCV RNA-positive patients who were treated was 27.0%, a 10.5% decrease from 2015 to 2019. CONCLUSION: An Ab positivity rate > 4-times higher than national estimates with increased screening among baby boomers, but decreased screening among younger individuals, suggests risk-based screening is still common practice in Florida, despite universal screening recommendations. Public health efforts to decrease barriers to screening, linkage to care, and treatment are needed to reduce the burden of HCV in Florida and to ensure progress toward virus elimination. Springer Healthcare 2021-12-16 2022-02 /pmc/articles/PMC8847470/ /pubmed/34914078 http://dx.doi.org/10.1007/s40121-021-00578-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Original Research
Thomas, Emmanuel
Cheng, Wei-Han
Dylla, Douglas E.
Marx, Steven E.
Carabino, Jana
Xu, Qingqing
Awareness and Epidemiology of Chronic Hepatitis C Virus Infections in Florida
title Awareness and Epidemiology of Chronic Hepatitis C Virus Infections in Florida
title_full Awareness and Epidemiology of Chronic Hepatitis C Virus Infections in Florida
title_fullStr Awareness and Epidemiology of Chronic Hepatitis C Virus Infections in Florida
title_full_unstemmed Awareness and Epidemiology of Chronic Hepatitis C Virus Infections in Florida
title_short Awareness and Epidemiology of Chronic Hepatitis C Virus Infections in Florida
title_sort awareness and epidemiology of chronic hepatitis c virus infections in florida
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847470/
https://www.ncbi.nlm.nih.gov/pubmed/34914078
http://dx.doi.org/10.1007/s40121-021-00578-5
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