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Inhibition of PDIA3 in club cells attenuates osteopontin production and lung fibrosis

BACKGROUND: The role of club cells in the pathology of idiopathic pulmonary fibrosis (IPF) is not well understood. Protein disulfide isomerase A3 (PDIA3), an endoplasmic reticulum-based redox chaperone required for the functions of various fibrosis-related proteins; however, the mechanisms of action...

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Detalles Bibliográficos
Autores principales:	Kumar, Amit, Elko, Evan, Bruno, Sierra R, Mark, Zoe F, Chamberlain, Nicolas, Mihavics, Bethany Korwin, Chandrasekaran, Ravishankar, Walzer, Joseph, Ruban, Mona, Gold, Clarissa, Lam, Ying Wai, Ghandikota, Sudhir, Jegga, Anil G, Gomez, Jose L, Janssen-Heininger, Yvonne MW, Anathy, Vikas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2022
Materias:	Interstitial Lung Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847543/ https://www.ncbi.nlm.nih.gov/pubmed/34400514 http://dx.doi.org/10.1136/thoraxjnl-2021-216882

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