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Biomechanical duality of fracture healing captured using virtual mechanical testing and validated in ovine bones

Bone fractures commonly repair by forming a bridging structure called callus, which begins as soft tissue and gradually ossifies to restore rigidity to the bone. Virtual mechanical testing is a promising technique for image-based assessment of structural bone healing in both preclinical and clinical...

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Autores principales: Inglis, Brendan, Schwarzenberg, Peter, Klein, Karina, von Rechenberg, Brigitte, Darwiche, Salim, Dailey, Hannah L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847550/
https://www.ncbi.nlm.nih.gov/pubmed/35169187
http://dx.doi.org/10.1038/s41598-022-06267-8
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author Inglis, Brendan
Schwarzenberg, Peter
Klein, Karina
von Rechenberg, Brigitte
Darwiche, Salim
Dailey, Hannah L.
author_facet Inglis, Brendan
Schwarzenberg, Peter
Klein, Karina
von Rechenberg, Brigitte
Darwiche, Salim
Dailey, Hannah L.
author_sort Inglis, Brendan
collection PubMed
description Bone fractures commonly repair by forming a bridging structure called callus, which begins as soft tissue and gradually ossifies to restore rigidity to the bone. Virtual mechanical testing is a promising technique for image-based assessment of structural bone healing in both preclinical and clinical settings, but its accuracy depends on the validity of the material model used to assign tissue mechanical properties. The goal of this study was to develop a constitutive model for callus that captures the heterogeneity and biomechanical duality of the callus, which contains both soft tissue and woven bone. To achieve this, a large-scale optimization analysis was performed on 2363 variations of 3D finite element models derived from computed tomography (CT) scans of 33 osteotomized sheep under normal and delayed healing conditions. A piecewise material model was identified that produced high absolute agreement between virtual and physical tests by differentiating between soft and hard callus based on radiodensity. The results showed that the structural integrity of a healing long bone is conferred by an internal architecture of mineralized hard callus that is supported by interstitial soft tissue. These findings suggest that with appropriate material modeling, virtual mechanical testing is a reliable surrogate for physical biomechanical testing.
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spelling pubmed-88475502022-02-17 Biomechanical duality of fracture healing captured using virtual mechanical testing and validated in ovine bones Inglis, Brendan Schwarzenberg, Peter Klein, Karina von Rechenberg, Brigitte Darwiche, Salim Dailey, Hannah L. Sci Rep Article Bone fractures commonly repair by forming a bridging structure called callus, which begins as soft tissue and gradually ossifies to restore rigidity to the bone. Virtual mechanical testing is a promising technique for image-based assessment of structural bone healing in both preclinical and clinical settings, but its accuracy depends on the validity of the material model used to assign tissue mechanical properties. The goal of this study was to develop a constitutive model for callus that captures the heterogeneity and biomechanical duality of the callus, which contains both soft tissue and woven bone. To achieve this, a large-scale optimization analysis was performed on 2363 variations of 3D finite element models derived from computed tomography (CT) scans of 33 osteotomized sheep under normal and delayed healing conditions. A piecewise material model was identified that produced high absolute agreement between virtual and physical tests by differentiating between soft and hard callus based on radiodensity. The results showed that the structural integrity of a healing long bone is conferred by an internal architecture of mineralized hard callus that is supported by interstitial soft tissue. These findings suggest that with appropriate material modeling, virtual mechanical testing is a reliable surrogate for physical biomechanical testing. Nature Publishing Group UK 2022-02-15 /pmc/articles/PMC8847550/ /pubmed/35169187 http://dx.doi.org/10.1038/s41598-022-06267-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Inglis, Brendan
Schwarzenberg, Peter
Klein, Karina
von Rechenberg, Brigitte
Darwiche, Salim
Dailey, Hannah L.
Biomechanical duality of fracture healing captured using virtual mechanical testing and validated in ovine bones
title Biomechanical duality of fracture healing captured using virtual mechanical testing and validated in ovine bones
title_full Biomechanical duality of fracture healing captured using virtual mechanical testing and validated in ovine bones
title_fullStr Biomechanical duality of fracture healing captured using virtual mechanical testing and validated in ovine bones
title_full_unstemmed Biomechanical duality of fracture healing captured using virtual mechanical testing and validated in ovine bones
title_short Biomechanical duality of fracture healing captured using virtual mechanical testing and validated in ovine bones
title_sort biomechanical duality of fracture healing captured using virtual mechanical testing and validated in ovine bones
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847550/
https://www.ncbi.nlm.nih.gov/pubmed/35169187
http://dx.doi.org/10.1038/s41598-022-06267-8
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