Macrophage Jak2 deficiency accelerates atherosclerosis through defects in cholesterol efflux

Atherosclerosis is a chronic inflammatory condition in which macrophages play a major role. Janus kinase 2 (JAK2) is a pivotal molecule in inflammatory and metabolic signaling, and Jak2(V617F) activating mutation has recently been implicated with enhancing clonal hematopoiesis and atherosclerosis. T...

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Detalles Bibliográficos
Autores principales: Dotan, Idit, Yang, Jiaqi, Ikeda, Jiro, Roth, Ziv, Pollock-Tahiri, Evan, Desai, Harsh, Sivasubramaniyam, Tharini, Rehal, Sonia, Rapps, Josh, Li, Yu Zhe, Le, Helen, Farber, Gedaliah, Alchami, Edouard, Xiao, Changting, Karim, Saraf, Gronda, Marcela, Saikali, Michael F., Tirosh, Amit, Wagner, Kay-Uwe, Genest, Jacques, Schimmer, Aaron D., Gupta, Vikas, Minden, Mark D., Cummins, Carolyn L., Lewis, Gary F., Robbins, Clinton, Jongstra-Bilen, Jenny, Cybulsky, Myron, Woo, Minna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847578/
https://www.ncbi.nlm.nih.gov/pubmed/35169231
http://dx.doi.org/10.1038/s42003-022-03078-5

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