Cargando…

Sleep macro- and microstructure in breast cancer survivors

Complaints of sleep disturbance are prevalent among breast cancer (BC) patients and are predictors of quality of life. Still, electrophysiological measures of sleep are missing in patients, which prevents from understanding the pathophysiological consequences of cancer and its past treatments. Using...

Descripción completa

Detalles Bibliográficos
Autores principales: Perrier, J., Duivon, M., Clochon, P., Rehel, S., Doidy, F., Grellard, J. M., Segura-Djezzar, C., Geffrelot, J., Emile, G., Allouache, D., Levy, C., Polvent, S., Viader, F., Eustache, F., Joly, F., Giffard, B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847579/
https://www.ncbi.nlm.nih.gov/pubmed/35169245
http://dx.doi.org/10.1038/s41598-022-06664-z
_version_ 1784652075119935488
author Perrier, J.
Duivon, M.
Clochon, P.
Rehel, S.
Doidy, F.
Grellard, J. M.
Segura-Djezzar, C.
Geffrelot, J.
Emile, G.
Allouache, D.
Levy, C.
Polvent, S.
Viader, F.
Eustache, F.
Joly, F.
Giffard, B.
author_facet Perrier, J.
Duivon, M.
Clochon, P.
Rehel, S.
Doidy, F.
Grellard, J. M.
Segura-Djezzar, C.
Geffrelot, J.
Emile, G.
Allouache, D.
Levy, C.
Polvent, S.
Viader, F.
Eustache, F.
Joly, F.
Giffard, B.
author_sort Perrier, J.
collection PubMed
description Complaints of sleep disturbance are prevalent among breast cancer (BC) patients and are predictors of quality of life. Still, electrophysiological measures of sleep are missing in patients, which prevents from understanding the pathophysiological consequences of cancer and its past treatments. Using polysomnography, sleep can be investigated in terms of macro- (e.g. awakenings, sleep stages) and micro- (i.e. cortical activity) structure. We aimed to characterize sleep complaints, and macro- and microstructure in 33 BC survivors untreated by chemotherapy and that had finished radiotherapy since at least 6 months (i.e. out of the acute effects of radiotherapy) compared to 21 healthy controls (HC). Compared to HC, BC patients had a larger number of awakenings (p = 0.008); and lower Delta power (p < 0.001), related to sleep deepening and homeostasis; greater both Alpha (p = 0.002) and Beta power (p < 0.001), related to arousal during deep sleep; and lower Theta power (p = 0.004), related to emotion regulation during dream sleep. Here we show that patients have increased cortical activity related to arousal and lower activity related to sleep homeostasis compared to controls. These results give additional insights in sleep pathophysiology of BC survivors and suggest sleep homeostasis disruption in non-advanced stages of BC.
format Online
Article
Text
id pubmed-8847579
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-88475792022-02-17 Sleep macro- and microstructure in breast cancer survivors Perrier, J. Duivon, M. Clochon, P. Rehel, S. Doidy, F. Grellard, J. M. Segura-Djezzar, C. Geffrelot, J. Emile, G. Allouache, D. Levy, C. Polvent, S. Viader, F. Eustache, F. Joly, F. Giffard, B. Sci Rep Article Complaints of sleep disturbance are prevalent among breast cancer (BC) patients and are predictors of quality of life. Still, electrophysiological measures of sleep are missing in patients, which prevents from understanding the pathophysiological consequences of cancer and its past treatments. Using polysomnography, sleep can be investigated in terms of macro- (e.g. awakenings, sleep stages) and micro- (i.e. cortical activity) structure. We aimed to characterize sleep complaints, and macro- and microstructure in 33 BC survivors untreated by chemotherapy and that had finished radiotherapy since at least 6 months (i.e. out of the acute effects of radiotherapy) compared to 21 healthy controls (HC). Compared to HC, BC patients had a larger number of awakenings (p = 0.008); and lower Delta power (p < 0.001), related to sleep deepening and homeostasis; greater both Alpha (p = 0.002) and Beta power (p < 0.001), related to arousal during deep sleep; and lower Theta power (p = 0.004), related to emotion regulation during dream sleep. Here we show that patients have increased cortical activity related to arousal and lower activity related to sleep homeostasis compared to controls. These results give additional insights in sleep pathophysiology of BC survivors and suggest sleep homeostasis disruption in non-advanced stages of BC. Nature Publishing Group UK 2022-02-15 /pmc/articles/PMC8847579/ /pubmed/35169245 http://dx.doi.org/10.1038/s41598-022-06664-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Perrier, J.
Duivon, M.
Clochon, P.
Rehel, S.
Doidy, F.
Grellard, J. M.
Segura-Djezzar, C.
Geffrelot, J.
Emile, G.
Allouache, D.
Levy, C.
Polvent, S.
Viader, F.
Eustache, F.
Joly, F.
Giffard, B.
Sleep macro- and microstructure in breast cancer survivors
title Sleep macro- and microstructure in breast cancer survivors
title_full Sleep macro- and microstructure in breast cancer survivors
title_fullStr Sleep macro- and microstructure in breast cancer survivors
title_full_unstemmed Sleep macro- and microstructure in breast cancer survivors
title_short Sleep macro- and microstructure in breast cancer survivors
title_sort sleep macro- and microstructure in breast cancer survivors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847579/
https://www.ncbi.nlm.nih.gov/pubmed/35169245
http://dx.doi.org/10.1038/s41598-022-06664-z
work_keys_str_mv AT perrierj sleepmacroandmicrostructureinbreastcancersurvivors
AT duivonm sleepmacroandmicrostructureinbreastcancersurvivors
AT clochonp sleepmacroandmicrostructureinbreastcancersurvivors
AT rehels sleepmacroandmicrostructureinbreastcancersurvivors
AT doidyf sleepmacroandmicrostructureinbreastcancersurvivors
AT grellardjm sleepmacroandmicrostructureinbreastcancersurvivors
AT seguradjezzarc sleepmacroandmicrostructureinbreastcancersurvivors
AT geffrelotj sleepmacroandmicrostructureinbreastcancersurvivors
AT emileg sleepmacroandmicrostructureinbreastcancersurvivors
AT allouached sleepmacroandmicrostructureinbreastcancersurvivors
AT levyc sleepmacroandmicrostructureinbreastcancersurvivors
AT polvents sleepmacroandmicrostructureinbreastcancersurvivors
AT viaderf sleepmacroandmicrostructureinbreastcancersurvivors
AT eustachef sleepmacroandmicrostructureinbreastcancersurvivors
AT jolyf sleepmacroandmicrostructureinbreastcancersurvivors
AT giffardb sleepmacroandmicrostructureinbreastcancersurvivors