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Induction of senescence-associated secretory phenotype underlies the therapeutic efficacy of PRC2 inhibition in cancer

The methyltransferase Polycomb Repressive Complex 2 (PRC2), composed of EZH2, SUZ12, and EED subunits, is associated with transcriptional repression via tri-methylation of histone H3 on lysine 27 residue (H3K27me3). PRC2 is a valid drug target, as the EZH2 gain-of-function mutations identified in pa...

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Detalles Bibliográficos
Autores principales:	Chu, Liping, Qu, Yuxiu, An, Yang, Hou, Linjun, Li, Juewan, Li, Weijia, Fan, Gaofeng, Song, Bao-Liang, Li, En, Zhang, Liye, Qi, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847585/ https://www.ncbi.nlm.nih.gov/pubmed/35169119 http://dx.doi.org/10.1038/s41419-022-04601-6

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