Cargando…

The Treatment With the SGLT2 Inhibitor Empagliflozin Modifies the Hepatic Metabolome of Male Zucker Diabetic Fatty Rats Towards a Protective Profile

The EMPA-REG OUTCOME (Empagliflozin, Cardiovascular Outcome Event Trial in patients with Type 2 Diabetes Mellitus (T2DM)) trial evidenced the potential of sodium-glucose cotransporter 2 (SGLT2) inhibitors for the treatment of patients with diabetes and cardiovascular disease. Recent evidences have s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Aragón-Herrera, Alana, Otero-Santiago, Manuel, Anido-Varela, Laura, Moraña-Fernández, Sandra, Campos-Toimil, Manuel, García-Caballero, Tomás, Barral, Luis, Tarazón, Estefanía, Roselló-Lletí, Esther, Portolés, Manuel, Gualillo, Oreste, Moscoso, Isabel, Lage, Ricardo, González-Juanatey, José Ramón, Feijóo-Bandín, Sandra, Lago, Francisca
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847595/ https://www.ncbi.nlm.nih.gov/pubmed/35185578 http://dx.doi.org/10.3389/fphar.2022.827033

Ejemplares similares

Adipokines and Inflammation: Focus on Cardiovascular Diseases
por: Feijóo-Bandín, Sandra, et al.
Publicado: (2020)

Relaxin-2 as a Potential Biomarker in Cardiovascular Diseases
por: Aragón-Herrera, Alana, et al.
Publicado: (2022)

Role of Sodium-Glucose Co-Transporter 2 Inhibitors in the Regulation of Inflammatory Processes in Animal Models
por: Feijóo-Bandín, Sandra, et al.
Publicado: (2022)

Relaxin-2 plasma levels in atrial fibrillation are linked to inflammation and oxidative stress markers
por: Aragón-Herrera, Alana, et al.
Publicado: (2022)

Relaxin-2 in Cardiometabolic Diseases: Mechanisms of Action and Future Perspectives
por: Feijóo-Bandín, Sandra, et al.
Publicado: (2017)

Circulating mitochondrial genes detect acute cardiac allograft rejection: Role of the mitochondrial calcium uniporter complex
por: Tarazón, Estefanía, et al.
Publicado: (2020)

Combining Serum miR-144-3p and miR-652-3p as Potential Biomarkers for the Early Diagnosis and Stratification of Acute Cellular Rejection in Heart Transplantation Patients
por: Pérez-Carrillo, Lorena, et al.
Publicado: (2023)

Cardiac Sodium/Hydrogen Exchanger (NHE11) as a Novel Potential Target for SGLT2i in Heart Failure: A Preliminary Study
por: Pérez-Carrillo, Lorena, et al.
Publicado: (2022)

Alpha-cardiac Actin Serum Expression Levels Detect Acute Cellular Rejection in Heart Transplant Patients
por: Pérez-Carrillo, Lorena, et al.
Publicado: (2023)

Altered MicroRNA Maturation in Ischemic Hearts: Implication of Hypoxia on XPO5 and DICER1 Dysregulation and RedoximiR State
por: Pérez-Carrillo, Lorena, et al.
Publicado: (2023)

Protocol for Isolation of Golgi Vesicles from Human and Animal Hearts by Flotation through a Discontinuous Sucrose Gradient
por: Tarazón, Estefanía, et al.
Publicado: (2020)

Electron Microscopy Reveals Evidence of Perinuclear Clustering of Mitochondria in Cardiac Biopsy-Proven Allograft Rejection
por: Tarazón, Estefanía, et al.
Publicado: (2022)

Human Ischemic Cardiomyopathy Shows Cardiac Nos1 Translocation and its Increased Levels are Related to Left Ventricular Performance
por: Roselló-Lletí, Esther, et al.
Publicado: (2016)

Protein Inhibitor of NOS1 Plays a Central Role in the Regulation of NOS1 Activity in Human Dilated Hearts
por: Roselló-Lletí, Esther, et al.
Publicado: (2016)

TRPM7 is down‐regulated in both left atria and left ventricle of ischaemic cardiomyopathy patients and highly related to changes in ventricular function
por: Ortega, Ana, et al.
Publicado: (2016)

ASB1 differential methylation in ischaemic cardiomyopathy: relationship with left ventricular performance in end‐stage heart failure patients
por: Ortega, Ana, et al.
Publicado: (2018)

Myocardium of patients with dilated cardiomyopathy presents altered expression of genes involved in thyroid hormone biosynthesis
por: Gil-Cayuela, Carolina, et al.
Publicado: (2018)

Heart Mitochondrial Proteome Study Elucidates Changes in Cardiac Energy Metabolism and Antioxidant PRDX3 in Human Dilated Cardiomyopathy
por: Roselló-Lletí, Esther, et al.
Publicado: (2014)

New Altered Non-Fibrillar Collagens in Human Dilated Cardiomyopathy: Role in the Remodeling Process
por: Gil-Cayuela, Carolina, et al.
Publicado: (2016)

XPO1 Gene Therapy Attenuates Cardiac Dysfunction in Rats with Chronic Induced Myocardial Infarction
por: García-Manzanares, María, et al.
Publicado: (2019)

Patients with Dilated Cardiomyopathy and Sustained Monomorphic Ventricular Tachycardia Show Up-Regulation of KCNN3 and KCNJ2 Genes and CACNG8-Linked Left Ventricular Dysfunction
por: Ortega, Ana, et al.
Publicado: (2015)

Circulating Sphingosine-1-Phosphate as A Non-Invasive Biomarker of Heart Transplant Rejection
por: Tarazón, Estefanía, et al.
Publicado: (2019)

Heart Failure Induces Significant Changes in Nuclear Pore Complex of Human Cardiomyocytes
por: Tarazón, Estefanía, et al.
Publicado: (2012)

Endoplasmic Reticulum Stress Induces Different Molecular Structural Alterations in Human Dilated and Ischemic Cardiomyopathy
por: Ortega, Ana, et al.
Publicado: (2014)

Intercalated disc in failing hearts from patients with dilated cardiomyopathy: Its role in the depressed left ventricular function
por: Ortega, Ana, et al.
Publicado: (2017)

Differential Gene Expression of Cardiac Ion Channels in Human Dilated Cardiomyopathy
por: Molina-Navarro, Maria Micaela, et al.
Publicado: (2013)

RNA Sequencing Analysis and Atrial Natriuretic Peptide Production in Patients with Dilated and Ischemic Cardiomyopathy
por: Tarazón, Estefanía, et al.
Publicado: (2014)

ATP synthase subunit alpha and LV mass in ischaemic human hearts
por: Roselló-Lletí, Esther, et al.
Publicado: (2015)

The altered expression of autophagy-related genes participates in heart failure: NRBP2 and CALCOCO2 are associated with left ventricular dysfunction parameters in human dilated cardiomyopathy
por: Gil-Cayuela, Carolina, et al.
Publicado: (2019)

MMP-2 and sTNF-R1 Variability in Patients with Essential Hypertension: 1-Year Follow-Up Study
por: Carpena, Núria, et al.
Publicado: (2012)

Relationships of Telomere Homeostasis with Oxidative Stress and Cardiac Dysfunction in Human Ischaemic Hearts
por: Tarazón, Estefanía, et al.
Publicado: (2021)

DNMT3B System Dysregulation Contributes to the Hypomethylated State in Ischaemic Human Hearts
por: Tarazón, Estefanía, et al.
Publicado: (2022)

Differences in MEF2 and NFAT Transcriptional Pathways According to Human Heart Failure Aetiology
por: Cortés, Raquel, et al.
Publicado: (2012)

Implication of Sphingolipid Metabolism Gene Dysregulation and Cardiac Sphingosine-1-Phosphate Accumulation in Heart Failure
por: Pérez-Carrillo, Lorena, et al.
Publicado: (2022)

Gene expression network analysis reveals new transcriptional regulators as novel factors in human ischemic cardiomyopathy
por: Herrer, Isabel, et al.
Publicado: (2015)

New Cell Adhesion Molecules in Human Ischemic Cardiomyopathy. PCDHGA3 Implications in Decreased Stroke Volume and Ventricular Dysfunction
por: Ortega, Ana, et al.
Publicado: (2016)

Cardiac protein changes in ischaemic and dilated cardiomyopathy: a proteomic study of human left ventricular tissue
por: Roselló-Lletí, Esther, et al.
Publicado: (2012)

Increased Expression of Fatty-Acid and Calcium Metabolism Genes in Failing Human Heart
por: García-Rúa, Vanessa, et al.
Publicado: (2012)

Cardiac Allograft Rejection Induces Changes in Nucleocytoplasmic Transport: RANGAP1 as a Potential Non-Invasive Biomarker
por: Lozano-Edo, Silvia, et al.
Publicado: (2022)

Empagliflozin-Associated Pancreatitis: A Consideration for SGLT2 Inhibitors
por: Dziadkowiec, Karolina N., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_2bsrsrs10edq440d3en6bpoacf