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The metabolomics profile of growth rate in grazing beef cattle

This study aimed to determine the relationship between the metabolome and changes in growth rate (i.e., liveweight change, LWC) and molasses-lick block supplement intake (MLB) of grazing cattle. Weaner beef cattle were fed for 220 days with a sequence of feed types and blood samples, growth rate, an...

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Autores principales: Imaz, José Augusto, García, Sergio, González, Luciano Adrián
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847617/
https://www.ncbi.nlm.nih.gov/pubmed/35169253
http://dx.doi.org/10.1038/s41598-022-06592-y
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author Imaz, José Augusto
García, Sergio
González, Luciano Adrián
author_facet Imaz, José Augusto
García, Sergio
González, Luciano Adrián
author_sort Imaz, José Augusto
collection PubMed
description This study aimed to determine the relationship between the metabolome and changes in growth rate (i.e., liveweight change, LWC) and molasses-lick block supplement intake (MLB) of grazing cattle. Weaner beef cattle were fed for 220 days with a sequence of feed types and blood samples, growth rate, and supplement intake were taken on five points in time. The relative abundance (RA) of plasma metabolites were determined using proton nuclear magnetic resonance (NMR). Sixty-four per cent of the metabolites identified were associated with LWC but only 26% with MLB intake (P < 0.05). Periods with faster growth rate showed high availability of amino acids (i.e., valine, leucine, isoleucine, phenylalanine and tyrosine), acetate, and 3-hydroxybutyrate. Periods with lower growth rate were associated with high RA of lipids, choline and acetate. The metabolic profile of individual animals during a period of compensatory growth (after periods of poor performance) showed that high-performing animals were characterised by lower RA of amino acids (i.e., valine, leucine, isoleucine, methylhistidine), creatinine, creatine, pyruvate, 3-hydroxybutyrate, and acetyl groups. It is speculated that high-performing animals have faster uptake of these metabolites from the bloodstream. Cattle growth rate over time was associated with their metabolome which could be used to ensure that the availability of certain metabolites promoting growth is tailored in feed supplements to improve production.
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spelling pubmed-88476172022-02-17 The metabolomics profile of growth rate in grazing beef cattle Imaz, José Augusto García, Sergio González, Luciano Adrián Sci Rep Article This study aimed to determine the relationship between the metabolome and changes in growth rate (i.e., liveweight change, LWC) and molasses-lick block supplement intake (MLB) of grazing cattle. Weaner beef cattle were fed for 220 days with a sequence of feed types and blood samples, growth rate, and supplement intake were taken on five points in time. The relative abundance (RA) of plasma metabolites were determined using proton nuclear magnetic resonance (NMR). Sixty-four per cent of the metabolites identified were associated with LWC but only 26% with MLB intake (P < 0.05). Periods with faster growth rate showed high availability of amino acids (i.e., valine, leucine, isoleucine, phenylalanine and tyrosine), acetate, and 3-hydroxybutyrate. Periods with lower growth rate were associated with high RA of lipids, choline and acetate. The metabolic profile of individual animals during a period of compensatory growth (after periods of poor performance) showed that high-performing animals were characterised by lower RA of amino acids (i.e., valine, leucine, isoleucine, methylhistidine), creatinine, creatine, pyruvate, 3-hydroxybutyrate, and acetyl groups. It is speculated that high-performing animals have faster uptake of these metabolites from the bloodstream. Cattle growth rate over time was associated with their metabolome which could be used to ensure that the availability of certain metabolites promoting growth is tailored in feed supplements to improve production. Nature Publishing Group UK 2022-02-15 /pmc/articles/PMC8847617/ /pubmed/35169253 http://dx.doi.org/10.1038/s41598-022-06592-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Imaz, José Augusto
García, Sergio
González, Luciano Adrián
The metabolomics profile of growth rate in grazing beef cattle
title The metabolomics profile of growth rate in grazing beef cattle
title_full The metabolomics profile of growth rate in grazing beef cattle
title_fullStr The metabolomics profile of growth rate in grazing beef cattle
title_full_unstemmed The metabolomics profile of growth rate in grazing beef cattle
title_short The metabolomics profile of growth rate in grazing beef cattle
title_sort metabolomics profile of growth rate in grazing beef cattle
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847617/
https://www.ncbi.nlm.nih.gov/pubmed/35169253
http://dx.doi.org/10.1038/s41598-022-06592-y
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