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Association between height loss and cardiovascular disease in the Korean elderly

Shorter people are at risk for cardiovascular disease (CVD), but data remain limited. This study sought to determine whether height loss is associated with an increased incidence of CVD. From the Korean National Health Insurance Service—Senior database (2002–2015), data of 134,952 individuals with a...

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Autores principales: Choi, Soo Jung, Lee, Rugyeom, Na, Yewon, Hwang, In Cheol, Jung, Jaehun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847618/
https://www.ncbi.nlm.nih.gov/pubmed/35169240
http://dx.doi.org/10.1038/s41598-022-06594-w
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author Choi, Soo Jung
Lee, Rugyeom
Na, Yewon
Hwang, In Cheol
Jung, Jaehun
author_facet Choi, Soo Jung
Lee, Rugyeom
Na, Yewon
Hwang, In Cheol
Jung, Jaehun
author_sort Choi, Soo Jung
collection PubMed
description Shorter people are at risk for cardiovascular disease (CVD), but data remain limited. This study sought to determine whether height loss is associated with an increased incidence of CVD. From the Korean National Health Insurance Service—Senior database (2002–2015), data of 134,952 individuals with available information on height loss was obtained. Height loss as percentages was measured 3–5 years from the baseline height. To assess hazard ratios for CVD incidence, multivariable Cox proportional hazard regression models were used before and after applying propensity score matching. The unmatched cohort consisted of 109,546 participants without height loss (< 1%): 20,208 participants with 1–2% height loss, and 5126 participants with ≥ 2% height loss. During a median follow-up period of 6.5 years (interquartile range, 3.7–8.5 years), 21,921 were newly diagnosed with CVD. Adults with height loss of > 2% had a greater risk of incident CVD than those with no height loss. This finding was statistically significant both in the original- and propensity score-matched cohorts. The increased risk for ischemic stroke was significant in the male subgroups, in line with degree of height loss. Overall, height loss is associated with an increased risk of subsequent ischemic stroke in Korean men.
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spelling pubmed-88476182022-02-17 Association between height loss and cardiovascular disease in the Korean elderly Choi, Soo Jung Lee, Rugyeom Na, Yewon Hwang, In Cheol Jung, Jaehun Sci Rep Article Shorter people are at risk for cardiovascular disease (CVD), but data remain limited. This study sought to determine whether height loss is associated with an increased incidence of CVD. From the Korean National Health Insurance Service—Senior database (2002–2015), data of 134,952 individuals with available information on height loss was obtained. Height loss as percentages was measured 3–5 years from the baseline height. To assess hazard ratios for CVD incidence, multivariable Cox proportional hazard regression models were used before and after applying propensity score matching. The unmatched cohort consisted of 109,546 participants without height loss (< 1%): 20,208 participants with 1–2% height loss, and 5126 participants with ≥ 2% height loss. During a median follow-up period of 6.5 years (interquartile range, 3.7–8.5 years), 21,921 were newly diagnosed with CVD. Adults with height loss of > 2% had a greater risk of incident CVD than those with no height loss. This finding was statistically significant both in the original- and propensity score-matched cohorts. The increased risk for ischemic stroke was significant in the male subgroups, in line with degree of height loss. Overall, height loss is associated with an increased risk of subsequent ischemic stroke in Korean men. Nature Publishing Group UK 2022-02-15 /pmc/articles/PMC8847618/ /pubmed/35169240 http://dx.doi.org/10.1038/s41598-022-06594-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Choi, Soo Jung
Lee, Rugyeom
Na, Yewon
Hwang, In Cheol
Jung, Jaehun
Association between height loss and cardiovascular disease in the Korean elderly
title Association between height loss and cardiovascular disease in the Korean elderly
title_full Association between height loss and cardiovascular disease in the Korean elderly
title_fullStr Association between height loss and cardiovascular disease in the Korean elderly
title_full_unstemmed Association between height loss and cardiovascular disease in the Korean elderly
title_short Association between height loss and cardiovascular disease in the Korean elderly
title_sort association between height loss and cardiovascular disease in the korean elderly
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847618/
https://www.ncbi.nlm.nih.gov/pubmed/35169240
http://dx.doi.org/10.1038/s41598-022-06594-w
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