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Periodontal inflamed surface area in oral cavity associated with febrile neutropenia in patients with hematologic malignancy undergoing chemotherapy
Febrile neutropenia (FN) is an infectious complication that develops during chemotherapy. Although the oral cavity can be an important infection route, it is unknown whether the oral environment is associated with FN. The present study examined the relationship between the oral environment using per...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847642/ https://www.ncbi.nlm.nih.gov/pubmed/35169215 http://dx.doi.org/10.1038/s41598-022-06485-0 |
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author | Nishi, Hiromi Ohta, Kouji Kuramoto, Yuri Shigeishi, Hideo Obayashi, Taiji Yoshioka, Yukio Konishi, Masaru Munenaga, Shuichi Nagoshi, Hisao Yoshida, Tetsumi Fukushima, Noriyasu Kakimoto, Naoya Ohge, Hiroki Kurihara, Hidemi Ichinohe, Tatsuo Kawaguchi, Hiroyuki |
author_facet | Nishi, Hiromi Ohta, Kouji Kuramoto, Yuri Shigeishi, Hideo Obayashi, Taiji Yoshioka, Yukio Konishi, Masaru Munenaga, Shuichi Nagoshi, Hisao Yoshida, Tetsumi Fukushima, Noriyasu Kakimoto, Naoya Ohge, Hiroki Kurihara, Hidemi Ichinohe, Tatsuo Kawaguchi, Hiroyuki |
author_sort | Nishi, Hiromi |
collection | PubMed |
description | Febrile neutropenia (FN) is an infectious complication that develops during chemotherapy. Although the oral cavity can be an important infection route, it is unknown whether the oral environment is associated with FN. The present study examined the relationship between the oral environment using periodontal inflamed surface area (PISA), a new periodontal disease parameter, and FN in hematologic cancer patients undergoing chemotherapy. In this retrospective cohort study, 157 patients were divided into FN onset during chemotherapy (n = 75) and the FN negative groups (n = 82). The associations of risk factors related to the intraoral environment were assessed. Logistic regression analysis showed that types of blood cancer (odds ratio 1.98; P < 0.01), use of a high-risk regimen (odds ratio 4.44; P < 0.05), prophylaxis treatment with human granulocyte colony-stimulating factor (G-CSF) (odds ratio 4.15; P < 0.01) and PISA (odds ratio 1.02; P < 0.01) were independent factors associated with FN onset. Finally, propensity score matching was performed between two groups; 37 matched pairs were generated. PISA was significantly higher in the FN group than the FN negative group. There was a significant relationship between PISA and FN onset (P = 0.035). The present findings indicate that periodontitis treatment before starting cancer treatment is recommended as supportive care for preventing FN onset during chemotherapy. |
format | Online Article Text |
id | pubmed-8847642 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-88476422022-02-17 Periodontal inflamed surface area in oral cavity associated with febrile neutropenia in patients with hematologic malignancy undergoing chemotherapy Nishi, Hiromi Ohta, Kouji Kuramoto, Yuri Shigeishi, Hideo Obayashi, Taiji Yoshioka, Yukio Konishi, Masaru Munenaga, Shuichi Nagoshi, Hisao Yoshida, Tetsumi Fukushima, Noriyasu Kakimoto, Naoya Ohge, Hiroki Kurihara, Hidemi Ichinohe, Tatsuo Kawaguchi, Hiroyuki Sci Rep Article Febrile neutropenia (FN) is an infectious complication that develops during chemotherapy. Although the oral cavity can be an important infection route, it is unknown whether the oral environment is associated with FN. The present study examined the relationship between the oral environment using periodontal inflamed surface area (PISA), a new periodontal disease parameter, and FN in hematologic cancer patients undergoing chemotherapy. In this retrospective cohort study, 157 patients were divided into FN onset during chemotherapy (n = 75) and the FN negative groups (n = 82). The associations of risk factors related to the intraoral environment were assessed. Logistic regression analysis showed that types of blood cancer (odds ratio 1.98; P < 0.01), use of a high-risk regimen (odds ratio 4.44; P < 0.05), prophylaxis treatment with human granulocyte colony-stimulating factor (G-CSF) (odds ratio 4.15; P < 0.01) and PISA (odds ratio 1.02; P < 0.01) were independent factors associated with FN onset. Finally, propensity score matching was performed between two groups; 37 matched pairs were generated. PISA was significantly higher in the FN group than the FN negative group. There was a significant relationship between PISA and FN onset (P = 0.035). The present findings indicate that periodontitis treatment before starting cancer treatment is recommended as supportive care for preventing FN onset during chemotherapy. Nature Publishing Group UK 2022-02-15 /pmc/articles/PMC8847642/ /pubmed/35169215 http://dx.doi.org/10.1038/s41598-022-06485-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Nishi, Hiromi Ohta, Kouji Kuramoto, Yuri Shigeishi, Hideo Obayashi, Taiji Yoshioka, Yukio Konishi, Masaru Munenaga, Shuichi Nagoshi, Hisao Yoshida, Tetsumi Fukushima, Noriyasu Kakimoto, Naoya Ohge, Hiroki Kurihara, Hidemi Ichinohe, Tatsuo Kawaguchi, Hiroyuki Periodontal inflamed surface area in oral cavity associated with febrile neutropenia in patients with hematologic malignancy undergoing chemotherapy |
title | Periodontal inflamed surface area in oral cavity associated with febrile neutropenia in patients with hematologic malignancy undergoing chemotherapy |
title_full | Periodontal inflamed surface area in oral cavity associated with febrile neutropenia in patients with hematologic malignancy undergoing chemotherapy |
title_fullStr | Periodontal inflamed surface area in oral cavity associated with febrile neutropenia in patients with hematologic malignancy undergoing chemotherapy |
title_full_unstemmed | Periodontal inflamed surface area in oral cavity associated with febrile neutropenia in patients with hematologic malignancy undergoing chemotherapy |
title_short | Periodontal inflamed surface area in oral cavity associated with febrile neutropenia in patients with hematologic malignancy undergoing chemotherapy |
title_sort | periodontal inflamed surface area in oral cavity associated with febrile neutropenia in patients with hematologic malignancy undergoing chemotherapy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847642/ https://www.ncbi.nlm.nih.gov/pubmed/35169215 http://dx.doi.org/10.1038/s41598-022-06485-0 |
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