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A gene signature consisting of ubiquitin ligases and deubiquitinating enzymes of SKP2 is associated with clinical outcome in breast cancer
The ubiquitination of SKP2, an oncoprotein, is controlled by its E3 ligases, including APC/C(FZR1) and deubiquitinases such as USP10. We identified a two-gene signature for the ubiquitination of SKP2, consisting of the copy number of FZR1 compared to the copy number of USP10. The signature reflects...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847659/ https://www.ncbi.nlm.nih.gov/pubmed/35169199 http://dx.doi.org/10.1038/s41598-022-06451-w |