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Evaluation of LipL32 and LigA/LigB Knockdown Mutants in Leptospira interrogans Serovar Copenhageni: Impacts to Proteome and Virulence

Leptospirosis is a worldwide zoonosis caused by pathogenic species of the genus Leptospira. The recent application of CRISPR interference (CRISPRi) to Leptospira facilitates targeted gene silencing and provides a new tool to investigate pathogenic mechanisms of leptospirosis. CRISPRi relies on the e...

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Detalles Bibliográficos
Autores principales:	Fernandes, Luis G. V., Putz, Ellie J., Stasko, Judith, Lippolis, John D., Nascimento, Ana L. T. O., Nally, Jarlath E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847714/ https://www.ncbi.nlm.nih.gov/pubmed/35185824 http://dx.doi.org/10.3389/fmicb.2021.799012

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