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Alterations of Regional Homogeneity in Crohn's Disease With Psychological Disorders: A Resting-State fMRI Study

Abnormal psychological processing in the central nervous system has been found in Crohn's disease (CD) patients. Resting-state functional magnetic resonance images of 57 inactive and 58 active CD patients, and 92 healthy controls (HC) were obtained. The psychological assessment used a psycholog...

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Autores principales: Huang, Mengting, Li, Xin, Fan, Wenliang, Li, Jing, Zhu, Liangru, Lei, Ping, Wu, Linxia, Sun, Qing, Zou, Yan, Han, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847745/
https://www.ncbi.nlm.nih.gov/pubmed/35185768
http://dx.doi.org/10.3389/fneur.2022.817556
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author Huang, Mengting
Li, Xin
Fan, Wenliang
Li, Jing
Zhu, Liangru
Lei, Ping
Wu, Linxia
Sun, Qing
Zou, Yan
Han, Ping
author_facet Huang, Mengting
Li, Xin
Fan, Wenliang
Li, Jing
Zhu, Liangru
Lei, Ping
Wu, Linxia
Sun, Qing
Zou, Yan
Han, Ping
author_sort Huang, Mengting
collection PubMed
description Abnormal psychological processing in the central nervous system has been found in Crohn's disease (CD) patients. Resting-state functional magnetic resonance images of 57 inactive and 58 active CD patients, and 92 healthy controls (HC) were obtained. The psychological assessment used a psychological questionnaire that was collected within 1 week before functional MRI examination. We investigated the neural basis of CD patients and the correlation among regional homogeneity (ReHo), clinical features and psychological assessment scores. We found that more severe psychological assessment disorder scores were observed in the active CD group than in the inactive CD group and HC group (P<0.001). Compared with HC, the active CD patients exhibited higher ReHo values in the frontal superior medial, frontal middle and lower values in the postcentral, supplementary motor area, and temporal middle. Meanwhile, inactive CD patients exhibited higher ReHo values in the frontal middle and lower ReHo values in the precentral, postcentral and putamen (all voxel P< 0.001, cluster P<0.01, corrected). The values of the frontal superior medial, postcentral and supplementary motor area were correlation with psychological assessment scores (r = 0.38, −0.41, −0.32, P = 0.001, 0.014, 0.003), and the clinical features of simple endoscopic score for Crohn's disease and erythrocyte sedimentation rate were negatively correlated with psychological assessment scores in active CD patients (r = −0.35, −0.34, P = 0.06, 0.08). These results provide evidence for abnormal resting-state brain activity in CD and suggest that the psychological of CD may play a critical role in brain function.
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spelling pubmed-88477452022-02-17 Alterations of Regional Homogeneity in Crohn's Disease With Psychological Disorders: A Resting-State fMRI Study Huang, Mengting Li, Xin Fan, Wenliang Li, Jing Zhu, Liangru Lei, Ping Wu, Linxia Sun, Qing Zou, Yan Han, Ping Front Neurol Neurology Abnormal psychological processing in the central nervous system has been found in Crohn's disease (CD) patients. Resting-state functional magnetic resonance images of 57 inactive and 58 active CD patients, and 92 healthy controls (HC) were obtained. The psychological assessment used a psychological questionnaire that was collected within 1 week before functional MRI examination. We investigated the neural basis of CD patients and the correlation among regional homogeneity (ReHo), clinical features and psychological assessment scores. We found that more severe psychological assessment disorder scores were observed in the active CD group than in the inactive CD group and HC group (P<0.001). Compared with HC, the active CD patients exhibited higher ReHo values in the frontal superior medial, frontal middle and lower values in the postcentral, supplementary motor area, and temporal middle. Meanwhile, inactive CD patients exhibited higher ReHo values in the frontal middle and lower ReHo values in the precentral, postcentral and putamen (all voxel P< 0.001, cluster P<0.01, corrected). The values of the frontal superior medial, postcentral and supplementary motor area were correlation with psychological assessment scores (r = 0.38, −0.41, −0.32, P = 0.001, 0.014, 0.003), and the clinical features of simple endoscopic score for Crohn's disease and erythrocyte sedimentation rate were negatively correlated with psychological assessment scores in active CD patients (r = −0.35, −0.34, P = 0.06, 0.08). These results provide evidence for abnormal resting-state brain activity in CD and suggest that the psychological of CD may play a critical role in brain function. Frontiers Media S.A. 2022-02-02 /pmc/articles/PMC8847745/ /pubmed/35185768 http://dx.doi.org/10.3389/fneur.2022.817556 Text en Copyright © 2022 Huang, Li, Fan, Li, Zhu, Lei, Wu, Sun, Zou and Han. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Huang, Mengting
Li, Xin
Fan, Wenliang
Li, Jing
Zhu, Liangru
Lei, Ping
Wu, Linxia
Sun, Qing
Zou, Yan
Han, Ping
Alterations of Regional Homogeneity in Crohn's Disease With Psychological Disorders: A Resting-State fMRI Study
title Alterations of Regional Homogeneity in Crohn's Disease With Psychological Disorders: A Resting-State fMRI Study
title_full Alterations of Regional Homogeneity in Crohn's Disease With Psychological Disorders: A Resting-State fMRI Study
title_fullStr Alterations of Regional Homogeneity in Crohn's Disease With Psychological Disorders: A Resting-State fMRI Study
title_full_unstemmed Alterations of Regional Homogeneity in Crohn's Disease With Psychological Disorders: A Resting-State fMRI Study
title_short Alterations of Regional Homogeneity in Crohn's Disease With Psychological Disorders: A Resting-State fMRI Study
title_sort alterations of regional homogeneity in crohn's disease with psychological disorders: a resting-state fmri study
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847745/
https://www.ncbi.nlm.nih.gov/pubmed/35185768
http://dx.doi.org/10.3389/fneur.2022.817556
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