Cargando…

The Search for Biomarkers and Treatments in Chagas Disease: Insights From TGF-Beta Studies and Immunogenetics

The anti-inflammatory cytokine transforming growth factor beta (TGF-β) plays an important role in Chagas disease (CD), a potentially life-threatening illness caused by Trypanosoma cruzi. In this review we revisited clinical studies in CD patients combined with in vitro and in vivo experiments, prese...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ferreira, Roberto Rodrigues, Waghabi, Mariana Caldas, Bailly, Sabine, Feige, Jean-Jacques, Hasslocher-Moreno, Alejandro M., Saraiva, Roberto M., Araujo-Jorge, Tania C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cellular and Infection Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847772/ https://www.ncbi.nlm.nih.gov/pubmed/35186778 http://dx.doi.org/10.3389/fcimb.2021.767576

Ejemplares similares

In Chagas disease, transforming growth factor beta neutralization reduces Trypanosoma cruzi infection and improves cardiac performance
por: Ferreira, Roberto Rodrigues, et al.
Publicado: (2022)

TGF-β Polymorphisms Are a Risk Factor for Chagas Disease
por: Ferreira, Roberto Rodrigues, et al.
Publicado: (2018)

Selenium, TGF-Beta and Infectious Endemic Cardiopathy: Lessons from Benchwork to Clinical Application in Chagas Disease
por: Araujo-Jorge, Tania C., et al.
Publicado: (2022)

Transforming growth factor-ß as a therapeutic target for the cardiac damage of Chagas disease
por: Waghabi, Mariana Caldas, et al.
Publicado: (2022)

Oral Administration of GW788388, an Inhibitor of Transforming Growth Factor Beta Signaling, Prevents Heart Fibrosis in Chagas Disease
por: de Oliveira, Fabiane L., et al.
Publicado: (2012)

TGF-β inhibitor therapy decreases fibrosis and stimulates cardiac improvement in a pre-clinical study of chronic Chagas’ heart disease
por: Ferreira, Roberto Rodrigues, et al.
Publicado: (2019)

Cruzipain Activates Latent TGF-β from Host Cells during T. cruzi Invasion
por: Ferrão, Patrícia Mello, et al.
Publicado: (2015)

Indeterminate form of Chagas disease: historical, conceptual, clinical, and prognostic aspects
por: Hasslocher-Moreno, Alejandro Marcel, et al.
Publicado: (2021)

Letters to the Editor: Indeterminate form of Chagas Disease: some immunological insights
por: Hasslocher-Moreno, Alejandro Marcel, et al.
Publicado: (2022)

Gut Dysbiosis in Chagas Disease. A Possible Link to the Pathogenesis
por: de Souza-Basqueira, Marcela, et al.
Publicado: (2020)

Toxoplasma gondii Impairs Myogenesis in vitro, With Changes in Myogenic Regulatory Factors, Altered Host Cell Proliferation and Secretory Profile
por: Vieira, Paloma de Carvalho, et al.
Publicado: (2019)

The repositioned drugs disulfiram/diethyldithiocarbamate combined to benznidazole: Searching for Chagas disease selective therapy, preventing toxicity and drug resistance
por: Almeida-Silva, Juliana, et al.
Publicado: (2022)

Circulating MicroRNAs and myocardial involvement severity in chronic Chagas cardiomyopathy
por: Gómez-Ochoa, Sergio Alejandro, et al.
Publicado: (2022)

Editorial: World Chagas disease day 2022
por: Palmisano, Giuseppe, et al.
Publicado: (2023)

Discovery and Genetic Validation of Chemotherapeutic Targets for Chagas' Disease
por: Osorio-Méndez, Juan Felipe, et al.
Publicado: (2019)

Editorial: Chagas disease novel drug targets and treatments
por: Duschak, Vilma G., et al.
Publicado: (2023)

Trypanosoma cruzi trans-Sialidase as a Potential Vaccine Target Against Chagas Disease
por: da Costa, Kelli Monteiro, et al.
Publicado: (2021)

Trypanosoma Species in Small Nonflying Mammals in an Area With a Single Previous Chagas Disease Case
por: Dario, Maria Augusta, et al.
Publicado: (2022)

Chagas Immunochromatographic Rapid Test in the Serological Diagnosis of Trypanosoma cruzi Infection in Wild and Domestic Canids
por: Rodrigues, Esthefany S., et al.
Publicado: (2022)

Characterization and Follow-Up of Trypanosoma cruzi Natural Populations Refractory to Etiological Chemotherapy in Oral Chagas Disease Patients
por: Muñoz-Calderón, Arturo, et al.
Publicado: (2021)

Air Pollution’s Impact on Cardiac Remodeling in an Experimental Model of Chagas Cardiomyopathy
por: Fonseca, Keila Cardoso Barbosa, et al.
Publicado: (2022)

Role of the Complement System in the Modulation of T-Cell Responses in Chronic Chagas Disease
por: Caputo, María Belén, et al.
Publicado: (2022)

Leishmaniasis and Chagas disease: Is there hope in nanotechnology to fight neglected tropical diseases?
por: Scariot, Debora B., et al.
Publicado: (2022)

Re: “Immunothrombotic dysregulation in chagas disease and COVID‑19: a comparative study of anticoagulation”
por: Hasslocher-Moreno, Alejandro Marcel
Publicado: (2022)

Archaea Symbiont of T. cruzi Infection May Explain Heart Failure in Chagas Disease
por: Higuchi, Maria de Lourdes, et al.
Publicado: (2018)

Sirtuin Control of Mitochondrial Dysfunction, Oxidative Stress, and Inflammation in Chagas Disease Models
por: Wan, Xianxiu, et al.
Publicado: (2021)

Trypanosomatid Richness Among Rats, Opossums, and Dogs in the Caatinga Biome, Northeast Brazil, a Former Endemic Area of Chagas Disease
por: Dario, Maria Augusta, et al.
Publicado: (2022)

Trypanosoma cruzi Induces Regulatory B Cell Alterations in Patients With Chronic Chagas Disease
por: Girard, Magalí C., et al.
Publicado: (2021)

Does Autoimmunity Play a Role in the Immunopathogenesis of Vasculitis Associated With Chronic Chagas Disease?
por: Garcia-Bustos, Victor, et al.
Publicado: (2021)

Immunomodulation for the Treatment of Chronic Chagas Disease Cardiomyopathy: A New Approach to an Old Enemy
por: Santos, Emanuelle de Souza, et al.
Publicado: (2021)

Matrix Metalloproteinase 2 and 9 Enzymatic Activities are Selectively Increased in the Myocardium of Chronic Chagas Disease Cardiomyopathy Patients: Role of TIMPs
por: Baron, Monique Andrade, et al.
Publicado: (2022)

Ageing with Chagas disease: an overview of an urban Brazilian cohort in Rio de Janeiro
por: Vizzoni, Alexandre Gomes, et al.
Publicado: (2018)

Circulating T Follicular Helper Cell Abnormalities Associated to Different Clinical Forms of Chronic Chagas Disease
por: Quebrada Palacio, Luz P., et al.
Publicado: (2020)

Hallmarks of the relationship between host and Trypanosoma cruzi sulfated glycoconjugates along the course of Chagas disease
por: Soprano, Luciana L., et al.
Publicado: (2023)

Precision Health for Chagas Disease: Integrating Parasite and Host Factors to Predict Outcome of Infection and Response to Therapy
por: Martinez, Santiago J., et al.
Publicado: (2020)

Differential Expression of Immune Response Genes in Asymptomatic Chronic Chagas Disease Patients Versus Healthy Subjects
por: Gómez, Inmaculada, et al.
Publicado: (2021)

Treatment With Suboptimal Dose of Benznidazole Mitigates Immune Response Molecular Pathways in Mice With Chronic Chagas Cardiomyopathy
por: Farani, Priscila Silva Grijó, et al.
Publicado: (2021)

The Role of the Na(+)/Ca(2+) Exchanger in Aberrant Intracellular Ca(2+) in Cardiomyocytes of Chagas-Infected Rodents
por: Lopez, Jose R., et al.
Publicado: (2022)

Vaccine-linked chemotherapy improves cardiac structure and function in a mouse model of chronic Chagas disease
por: Jones, Kathryn M., et al.
Publicado: (2023)

Re: “Challenges of addressing neglected tropical diseases amidst the COVID-19 pandemic in Africa: A case of Chagas Disease”
por: Hasslocher-Moreno, Alejandro Marcel
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_g7ugci8a57e8tevn3l43oaoa06