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Immune Characteristics of LYN in Tumor Microenvironment of Gliomas

The prognosis of gliomas is poor and there are limited therapeutic approaches. Immunotherapy has become a promising treatment for gliomas. Here, we explored the expression pattern of Lck/yes-related protein tyrosine kinase (LYN) in gliomas and assessed its value as an immunotherapy biomarker. Transc...

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Autores principales: Jiang, Chonghua, Zhang, Hao, Wu, Wantao, Wang, Zeyu, Dai, Ziyu, Zhang, Liyang, Liu, Zhixiong, Cheng, Quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847791/
https://www.ncbi.nlm.nih.gov/pubmed/35186945
http://dx.doi.org/10.3389/fcell.2021.760929
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author Jiang, Chonghua
Zhang, Hao
Wu, Wantao
Wang, Zeyu
Dai, Ziyu
Zhang, Liyang
Liu, Zhixiong
Cheng, Quan
author_facet Jiang, Chonghua
Zhang, Hao
Wu, Wantao
Wang, Zeyu
Dai, Ziyu
Zhang, Liyang
Liu, Zhixiong
Cheng, Quan
author_sort Jiang, Chonghua
collection PubMed
description The prognosis of gliomas is poor and there are limited therapeutic approaches. Immunotherapy has become a promising treatment for gliomas. Here, we explored the expression pattern of Lck/yes-related protein tyrosine kinase (LYN) in gliomas and assessed its value as an immunotherapy biomarker. Transcriptional data was mined from two publicly available datasets, TCGA and CGGA, and used to investigate the correlation between LYN and clinical characteristics including patient prognosis, somatic mutation, and immune infiltrating features in gliomas. Besides, the correlation between LYN and classical immune checkpoint molecules was explored. Glioma samples obtained from the Xiangya Hospital cohort were used for immunohistochemistry staining. High expression level of LYN was observed in advanced gliomas and other cancer types, which predicted a worse prognosis. LYN stratified patients’ survival in the Xiangya cohort and was also significantly associated with infiltrating immune cell types and inflammatory activities in the tumor microenvironment. LYN was involved in tumor mutation, correlated with the regulation of oncogenic genes, and also showed a significant positive correlation with PD-L1. LYN can be a potential diagnostic marker and immunotherapy marker in gliomas.
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spelling pubmed-88477912022-02-17 Immune Characteristics of LYN in Tumor Microenvironment of Gliomas Jiang, Chonghua Zhang, Hao Wu, Wantao Wang, Zeyu Dai, Ziyu Zhang, Liyang Liu, Zhixiong Cheng, Quan Front Cell Dev Biol Cell and Developmental Biology The prognosis of gliomas is poor and there are limited therapeutic approaches. Immunotherapy has become a promising treatment for gliomas. Here, we explored the expression pattern of Lck/yes-related protein tyrosine kinase (LYN) in gliomas and assessed its value as an immunotherapy biomarker. Transcriptional data was mined from two publicly available datasets, TCGA and CGGA, and used to investigate the correlation between LYN and clinical characteristics including patient prognosis, somatic mutation, and immune infiltrating features in gliomas. Besides, the correlation between LYN and classical immune checkpoint molecules was explored. Glioma samples obtained from the Xiangya Hospital cohort were used for immunohistochemistry staining. High expression level of LYN was observed in advanced gliomas and other cancer types, which predicted a worse prognosis. LYN stratified patients’ survival in the Xiangya cohort and was also significantly associated with infiltrating immune cell types and inflammatory activities in the tumor microenvironment. LYN was involved in tumor mutation, correlated with the regulation of oncogenic genes, and also showed a significant positive correlation with PD-L1. LYN can be a potential diagnostic marker and immunotherapy marker in gliomas. Frontiers Media S.A. 2022-02-02 /pmc/articles/PMC8847791/ /pubmed/35186945 http://dx.doi.org/10.3389/fcell.2021.760929 Text en Copyright © 2022 Jiang, Zhang, Wu, Wang, Dai, Zhang, Liu and Cheng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Jiang, Chonghua
Zhang, Hao
Wu, Wantao
Wang, Zeyu
Dai, Ziyu
Zhang, Liyang
Liu, Zhixiong
Cheng, Quan
Immune Characteristics of LYN in Tumor Microenvironment of Gliomas
title Immune Characteristics of LYN in Tumor Microenvironment of Gliomas
title_full Immune Characteristics of LYN in Tumor Microenvironment of Gliomas
title_fullStr Immune Characteristics of LYN in Tumor Microenvironment of Gliomas
title_full_unstemmed Immune Characteristics of LYN in Tumor Microenvironment of Gliomas
title_short Immune Characteristics of LYN in Tumor Microenvironment of Gliomas
title_sort immune characteristics of lyn in tumor microenvironment of gliomas
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847791/
https://www.ncbi.nlm.nih.gov/pubmed/35186945
http://dx.doi.org/10.3389/fcell.2021.760929
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