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Metabotropic Glutamate Receptor 5 Antagonism Reduces Pathology and Differentially Improves Symptoms in Male and Female Heterozygous zQ175 Huntington’s Mice

Huntington’s disease (HD) is an inherited autosomal dominant neurodegenerative disorder that leads to progressive motor and cognitive impairment. There are currently no available disease modifying treatments for HD patients. We have previously shown that pharmacological blockade of metabotropic glut...

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Detalles Bibliográficos
Autores principales:	Li, Si Han, Colson, Tash-Lynn L., Abd-Elrahman, Khaled S., Ferguson, Stephen S. G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Molecular Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847794/ https://www.ncbi.nlm.nih.gov/pubmed/35185467 http://dx.doi.org/10.3389/fnmol.2022.801757

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