SIK2 kinase synthetic lethality is driven by spindle assembly defects in FANCA‐deficient cells

The Fanconi anemia (FA) pathway safeguards genomic stability through cell cycle regulation and DNA damage repair. The canonical tumor suppressive role of FA proteins in the repair of DNA damage during interphase is well established, but their function in mitosis is incompletely understood. Here, we...

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Detalles Bibliográficos
Autores principales: Chan, Ka‐Kui, Abdul‐Sater, Zahi, Sheth, Aditya, Mitchell, Dana K., Sharma, Richa, Edwards, Donna M., He, Ying, Nalepa, Grzegorz, Rhodes, Steven D., Clapp, D. Wade, Sierra Potchanant, Elizabeth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8847993/
https://www.ncbi.nlm.nih.gov/pubmed/34058059
http://dx.doi.org/10.1002/1878-0261.13027

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