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Unveiling antimicrobial activity of microalgae Chlorella sorokiniana (UKM2), Chlorella sp. (UKM8) and Scenedesmus sp. (UKM9)

Microalgae represent promising sources of bioactive compounds for pharmaceutical and industrial applications. The emergence of antibiotic resistant bacteria leads to the need to explore new cost-effective, safe, and potent bioactive compounds from the microalgae. This study aimed to investigate the...

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Autores principales: Shaima, Abdul Fattah, Mohd Yasin, Nazlina Haiza, Ibrahim, Nazlina, Takriff, Mohd Sobri, Gunasekaran, Darvien, Ismaeel, Mahmud Y.Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8848016/
https://www.ncbi.nlm.nih.gov/pubmed/35197773
http://dx.doi.org/10.1016/j.sjbs.2021.09.069
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author Shaima, Abdul Fattah
Mohd Yasin, Nazlina Haiza
Ibrahim, Nazlina
Takriff, Mohd Sobri
Gunasekaran, Darvien
Ismaeel, Mahmud Y.Y.
author_facet Shaima, Abdul Fattah
Mohd Yasin, Nazlina Haiza
Ibrahim, Nazlina
Takriff, Mohd Sobri
Gunasekaran, Darvien
Ismaeel, Mahmud Y.Y.
author_sort Shaima, Abdul Fattah
collection PubMed
description Microalgae represent promising sources of bioactive compounds for pharmaceutical and industrial applications. The emergence of antibiotic resistant bacteria leads to the need to explore new cost-effective, safe, and potent bioactive compounds from the microalgae. This study aimed to investigate the potential of local microalgae for their antimicrobial properties and bioactive compounds. Three local microalgae namely Chlorella sorokiniana (UKM2), Chlorella sp. UKM8, and Scenedesmus sp. UKM9 biomass methanol extracts (ME) were prepared and tested against Gram-positive and Gram-negative bacteria. Chlorella sp. UKM8-ME showed the highest antibacterial activity. UKM8-ME minimum inhibitory concentrations were in the range of 0.312 to 6.25 mg/mL. Cytotoxicity evaluation using MTT assay showed that the microalgae methanolic extracts did not exhibit cytotoxicity against Vero-cells. The UKM8-ME was mainly containing 28 compounds from the Gas Chromatography-Mass Spectrometry (GC–MS) analysis. Major compounds of UKM8-ME included phenol (18.5%), hexadecanoic acid (18.25%), phytol (14.43%), 9,12-octadecadienoic acid (13.69%), and bicyclo[3.1.1]heptane (7.23%), which have been previously described to possess antimicrobial activity. Hence, Chlorella sp. (UKM8) methanol extracts showed promising antibacterial activity. More comprehensive studies are required to purify these antimicrobial compounds and develop our understanding on their mechanism in UKM8-ME to unleash their specific potential.
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spelling pubmed-88480162022-02-22 Unveiling antimicrobial activity of microalgae Chlorella sorokiniana (UKM2), Chlorella sp. (UKM8) and Scenedesmus sp. (UKM9) Shaima, Abdul Fattah Mohd Yasin, Nazlina Haiza Ibrahim, Nazlina Takriff, Mohd Sobri Gunasekaran, Darvien Ismaeel, Mahmud Y.Y. Saudi J Biol Sci Original Article Microalgae represent promising sources of bioactive compounds for pharmaceutical and industrial applications. The emergence of antibiotic resistant bacteria leads to the need to explore new cost-effective, safe, and potent bioactive compounds from the microalgae. This study aimed to investigate the potential of local microalgae for their antimicrobial properties and bioactive compounds. Three local microalgae namely Chlorella sorokiniana (UKM2), Chlorella sp. UKM8, and Scenedesmus sp. UKM9 biomass methanol extracts (ME) were prepared and tested against Gram-positive and Gram-negative bacteria. Chlorella sp. UKM8-ME showed the highest antibacterial activity. UKM8-ME minimum inhibitory concentrations were in the range of 0.312 to 6.25 mg/mL. Cytotoxicity evaluation using MTT assay showed that the microalgae methanolic extracts did not exhibit cytotoxicity against Vero-cells. The UKM8-ME was mainly containing 28 compounds from the Gas Chromatography-Mass Spectrometry (GC–MS) analysis. Major compounds of UKM8-ME included phenol (18.5%), hexadecanoic acid (18.25%), phytol (14.43%), 9,12-octadecadienoic acid (13.69%), and bicyclo[3.1.1]heptane (7.23%), which have been previously described to possess antimicrobial activity. Hence, Chlorella sp. (UKM8) methanol extracts showed promising antibacterial activity. More comprehensive studies are required to purify these antimicrobial compounds and develop our understanding on their mechanism in UKM8-ME to unleash their specific potential. Elsevier 2022-02 2021-10-02 /pmc/articles/PMC8848016/ /pubmed/35197773 http://dx.doi.org/10.1016/j.sjbs.2021.09.069 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Original Article
Shaima, Abdul Fattah
Mohd Yasin, Nazlina Haiza
Ibrahim, Nazlina
Takriff, Mohd Sobri
Gunasekaran, Darvien
Ismaeel, Mahmud Y.Y.
Unveiling antimicrobial activity of microalgae Chlorella sorokiniana (UKM2), Chlorella sp. (UKM8) and Scenedesmus sp. (UKM9)
title Unveiling antimicrobial activity of microalgae Chlorella sorokiniana (UKM2), Chlorella sp. (UKM8) and Scenedesmus sp. (UKM9)
title_full Unveiling antimicrobial activity of microalgae Chlorella sorokiniana (UKM2), Chlorella sp. (UKM8) and Scenedesmus sp. (UKM9)
title_fullStr Unveiling antimicrobial activity of microalgae Chlorella sorokiniana (UKM2), Chlorella sp. (UKM8) and Scenedesmus sp. (UKM9)
title_full_unstemmed Unveiling antimicrobial activity of microalgae Chlorella sorokiniana (UKM2), Chlorella sp. (UKM8) and Scenedesmus sp. (UKM9)
title_short Unveiling antimicrobial activity of microalgae Chlorella sorokiniana (UKM2), Chlorella sp. (UKM8) and Scenedesmus sp. (UKM9)
title_sort unveiling antimicrobial activity of microalgae chlorella sorokiniana (ukm2), chlorella sp. (ukm8) and scenedesmus sp. (ukm9)
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8848016/
https://www.ncbi.nlm.nih.gov/pubmed/35197773
http://dx.doi.org/10.1016/j.sjbs.2021.09.069
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