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Ginseng for the Treatment of Chronic Fatigue Syndrome: A Systematic Review of Clinical Studies

BACKGROUND: Chronic fatigue syndrome (CFS) is a complex and often disabling chronic condition emerging worldwide, with no curative or definitive therapy yet identified. Ginseng has been widely used to treat fatigue in other patient groups and conditions; however, a systematic review focusing solely...

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Autores principales: Yang, Juan, Shin, Kyung-Min, Abu Dabrh, Abd Moain, Bierle, Dennis M, Zhou, Xuan, Bauer, Brent A., Mohabbat, Arya B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8848096/
https://www.ncbi.nlm.nih.gov/pubmed/35186446
http://dx.doi.org/10.1177/2164957X221079790
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author Yang, Juan
Shin, Kyung-Min
Abu Dabrh, Abd Moain
Bierle, Dennis M
Zhou, Xuan
Bauer, Brent A.
Mohabbat, Arya B
author_facet Yang, Juan
Shin, Kyung-Min
Abu Dabrh, Abd Moain
Bierle, Dennis M
Zhou, Xuan
Bauer, Brent A.
Mohabbat, Arya B
author_sort Yang, Juan
collection PubMed
description BACKGROUND: Chronic fatigue syndrome (CFS) is a complex and often disabling chronic condition emerging worldwide, with no curative or definitive therapy yet identified. Ginseng has been widely used to treat fatigue in other patient groups and conditions; however, a systematic review focusing solely on the impact of ginseng on fatigue in patients with CFS has not been performed. OBJECTIVE: This study aimed to assess the current state of evidence regarding ginseng for CFS. METHODS: Multiple databases were searched from inception to October 2020. All data was extracted independently and in duplicates. Outcomes of interest included the effectiveness and safety of ginseng in patients with CFS. RESULTS: 2 studies enrolling 68 patients were deemed eligible, including one randomized clinical trial and one prospective observational study. The certainty of evidence in the effectiveness outcome was low and moderate from both studies, while the safety evidence was very low as reported from one study. CONCLUSION: Study findings highlight a potential benefit of ginseng therapy in the treatment of CFS. However, we are not able to draw firm conclusions due to limited clinical studies. The paucity of data warrants limited confidence. There is a need for future rigorous studies to provide further evidence.
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spelling pubmed-88480962022-02-17 Ginseng for the Treatment of Chronic Fatigue Syndrome: A Systematic Review of Clinical Studies Yang, Juan Shin, Kyung-Min Abu Dabrh, Abd Moain Bierle, Dennis M Zhou, Xuan Bauer, Brent A. Mohabbat, Arya B Glob Adv Health Med Systematic Review and Meta-analyses BACKGROUND: Chronic fatigue syndrome (CFS) is a complex and often disabling chronic condition emerging worldwide, with no curative or definitive therapy yet identified. Ginseng has been widely used to treat fatigue in other patient groups and conditions; however, a systematic review focusing solely on the impact of ginseng on fatigue in patients with CFS has not been performed. OBJECTIVE: This study aimed to assess the current state of evidence regarding ginseng for CFS. METHODS: Multiple databases were searched from inception to October 2020. All data was extracted independently and in duplicates. Outcomes of interest included the effectiveness and safety of ginseng in patients with CFS. RESULTS: 2 studies enrolling 68 patients were deemed eligible, including one randomized clinical trial and one prospective observational study. The certainty of evidence in the effectiveness outcome was low and moderate from both studies, while the safety evidence was very low as reported from one study. CONCLUSION: Study findings highlight a potential benefit of ginseng therapy in the treatment of CFS. However, we are not able to draw firm conclusions due to limited clinical studies. The paucity of data warrants limited confidence. There is a need for future rigorous studies to provide further evidence. SAGE Publications 2022-02-14 /pmc/articles/PMC8848096/ /pubmed/35186446 http://dx.doi.org/10.1177/2164957X221079790 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Systematic Review and Meta-analyses
Yang, Juan
Shin, Kyung-Min
Abu Dabrh, Abd Moain
Bierle, Dennis M
Zhou, Xuan
Bauer, Brent A.
Mohabbat, Arya B
Ginseng for the Treatment of Chronic Fatigue Syndrome: A Systematic Review of Clinical Studies
title Ginseng for the Treatment of Chronic Fatigue Syndrome: A Systematic Review of Clinical Studies
title_full Ginseng for the Treatment of Chronic Fatigue Syndrome: A Systematic Review of Clinical Studies
title_fullStr Ginseng for the Treatment of Chronic Fatigue Syndrome: A Systematic Review of Clinical Studies
title_full_unstemmed Ginseng for the Treatment of Chronic Fatigue Syndrome: A Systematic Review of Clinical Studies
title_short Ginseng for the Treatment of Chronic Fatigue Syndrome: A Systematic Review of Clinical Studies
title_sort ginseng for the treatment of chronic fatigue syndrome: a systematic review of clinical studies
topic Systematic Review and Meta-analyses
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8848096/
https://www.ncbi.nlm.nih.gov/pubmed/35186446
http://dx.doi.org/10.1177/2164957X221079790
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