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Aspirin Repurposing in Folate-Decorated Nanoparticles: Another Way to Target Breast Cancer

Breast cancer affects more than 1 million women per year worldwide. Through this study, we developed a nanoparticle-based drug delivery system to target breast cancer cells. Aspirin has been found to inhibit thromboembolic diseases with its tumor-preventing activity. As a consequence, it relieves di...

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Autores principales: Kanwal, Fariha, Ma, Mingming, Rehman, Muhammad Fayyaz ur, Khan, Fahim-ullah, Elizur, Shai E., Batool, Aima Iram, Wang, Chi Chiu, Tabassum, Tahira, Lu, Changrui, Wang, Yao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8848101/
https://www.ncbi.nlm.nih.gov/pubmed/35187067
http://dx.doi.org/10.3389/fmolb.2021.788279
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author Kanwal, Fariha
Ma, Mingming
Rehman, Muhammad Fayyaz ur
Khan, Fahim-ullah
Elizur, Shai E.
Batool, Aima Iram
Wang, Chi Chiu
Tabassum, Tahira
Lu, Changrui
Wang, Yao
author_facet Kanwal, Fariha
Ma, Mingming
Rehman, Muhammad Fayyaz ur
Khan, Fahim-ullah
Elizur, Shai E.
Batool, Aima Iram
Wang, Chi Chiu
Tabassum, Tahira
Lu, Changrui
Wang, Yao
author_sort Kanwal, Fariha
collection PubMed
description Breast cancer affects more than 1 million women per year worldwide. Through this study, we developed a nanoparticle-based drug delivery system to target breast cancer cells. Aspirin has been found to inhibit thromboembolic diseases with its tumor-preventing activity. As a consequence, it relieves disease symptoms and severity. Here, mesoporous silica nanoparticles (MNPs) have been used to deliver aspirin to the tumor location. MNP-based aspirin in folic acid (F)-conjugated polydopamine (MNP-Asp-PD-PG-F) vehicles are prepared for targeted breast cancer therapy. The vehicle hinges on MNP altered with polymer polyethylene glycol (PG), polydopamine (PD), and F. The delivery vehicle was studied for in vitro drug release, cytotoxicity, and breast cancer cell proliferation. F-conjugated drug delivery vehicles let MNPs achieve an elevated targeting efficacy, ideal for cancer therapy. It was also observed that compared to free aspirin, our drug delivery system (MNP-Asp-PD-PG-F) has a higher cytotoxic and antiproliferative effect on breast cancer cells. The drug delivery system can be proposed as a targeted breast cancer therapy that could be further focused on other targeted cancer therapies. Delivering aspirin by the PD-PG-F system on the tumor sites promises a therapeutic potential for breast cancer treatment.
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spelling pubmed-88481012022-02-17 Aspirin Repurposing in Folate-Decorated Nanoparticles: Another Way to Target Breast Cancer Kanwal, Fariha Ma, Mingming Rehman, Muhammad Fayyaz ur Khan, Fahim-ullah Elizur, Shai E. Batool, Aima Iram Wang, Chi Chiu Tabassum, Tahira Lu, Changrui Wang, Yao Front Mol Biosci Molecular Biosciences Breast cancer affects more than 1 million women per year worldwide. Through this study, we developed a nanoparticle-based drug delivery system to target breast cancer cells. Aspirin has been found to inhibit thromboembolic diseases with its tumor-preventing activity. As a consequence, it relieves disease symptoms and severity. Here, mesoporous silica nanoparticles (MNPs) have been used to deliver aspirin to the tumor location. MNP-based aspirin in folic acid (F)-conjugated polydopamine (MNP-Asp-PD-PG-F) vehicles are prepared for targeted breast cancer therapy. The vehicle hinges on MNP altered with polymer polyethylene glycol (PG), polydopamine (PD), and F. The delivery vehicle was studied for in vitro drug release, cytotoxicity, and breast cancer cell proliferation. F-conjugated drug delivery vehicles let MNPs achieve an elevated targeting efficacy, ideal for cancer therapy. It was also observed that compared to free aspirin, our drug delivery system (MNP-Asp-PD-PG-F) has a higher cytotoxic and antiproliferative effect on breast cancer cells. The drug delivery system can be proposed as a targeted breast cancer therapy that could be further focused on other targeted cancer therapies. Delivering aspirin by the PD-PG-F system on the tumor sites promises a therapeutic potential for breast cancer treatment. Frontiers Media S.A. 2022-01-28 /pmc/articles/PMC8848101/ /pubmed/35187067 http://dx.doi.org/10.3389/fmolb.2021.788279 Text en Copyright © 2022 Kanwal, Ma, Rehman, Khan, Elizur, Batool, Wang, Tabassum, Lu and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Kanwal, Fariha
Ma, Mingming
Rehman, Muhammad Fayyaz ur
Khan, Fahim-ullah
Elizur, Shai E.
Batool, Aima Iram
Wang, Chi Chiu
Tabassum, Tahira
Lu, Changrui
Wang, Yao
Aspirin Repurposing in Folate-Decorated Nanoparticles: Another Way to Target Breast Cancer
title Aspirin Repurposing in Folate-Decorated Nanoparticles: Another Way to Target Breast Cancer
title_full Aspirin Repurposing in Folate-Decorated Nanoparticles: Another Way to Target Breast Cancer
title_fullStr Aspirin Repurposing in Folate-Decorated Nanoparticles: Another Way to Target Breast Cancer
title_full_unstemmed Aspirin Repurposing in Folate-Decorated Nanoparticles: Another Way to Target Breast Cancer
title_short Aspirin Repurposing in Folate-Decorated Nanoparticles: Another Way to Target Breast Cancer
title_sort aspirin repurposing in folate-decorated nanoparticles: another way to target breast cancer
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8848101/
https://www.ncbi.nlm.nih.gov/pubmed/35187067
http://dx.doi.org/10.3389/fmolb.2021.788279
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