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Myeloid-Derived Suppressor Cells Are Increased in Lung Transplant Recipients and Regulated by Immunosuppressive Therapy
Lung transplantation remains as a primary treatment for end-stage lung diseases. Although remarkable improvement has been achieved due to the immunosuppressive protocols, long-term survival for lung transplant recipients (LTR) is still limited. In the last few decades, an increasing interest has gro...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8848105/ https://www.ncbi.nlm.nih.gov/pubmed/35185863 http://dx.doi.org/10.3389/fimmu.2021.788851 |
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author | Iglesias-Escudero, María Segundo, David San Merino-Fernandez, David Mora-Cuesta, Victor M. Lamadrid, Patricia Alonso-Peña, Marta Raso, Sandra Iturbe, David Fernandez-Rozas, Sonia Cifrian, Jose López-Hoyos, Marcos |
author_facet | Iglesias-Escudero, María Segundo, David San Merino-Fernandez, David Mora-Cuesta, Victor M. Lamadrid, Patricia Alonso-Peña, Marta Raso, Sandra Iturbe, David Fernandez-Rozas, Sonia Cifrian, Jose López-Hoyos, Marcos |
author_sort | Iglesias-Escudero, María |
collection | PubMed |
description | Lung transplantation remains as a primary treatment for end-stage lung diseases. Although remarkable improvement has been achieved due to the immunosuppressive protocols, long-term survival for lung transplant recipients (LTR) is still limited. In the last few decades, an increasing interest has grown in the study of dysregulation of immune mechanisms underlying allograft failure. In this regard, myeloid-derived suppressor cells (MDSCs) could play an important role in the promotion of graft tolerance due to their immune regulatory function. Here, we describe for the first time circulating subsets MDSCs from LTR at several time points and we evaluate the relationship of MDSCs with sort-term lung transplant outcomes. Although no effect of MDSCs subsets on short-term clinical events was observed, our results determine that Mo-MDSCs frequencies are increased after acute cellular rejection (ACR), suggesting a possible role for Mo-MDSCs in the development of chronic lung allograft dysfunction (CLAD). Therefore, whether MDSCs subsets play a role as biomarkers of chronic rejection remains unknown and requires further investigations. Also, the effects of the different immunosuppressive treatments on these subpopulations remain under research and further studies are needed to establish to what extend MDSCs immune modulation could be responsible for allograft acceptance. |
format | Online Article Text |
id | pubmed-8848105 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-88481052022-02-17 Myeloid-Derived Suppressor Cells Are Increased in Lung Transplant Recipients and Regulated by Immunosuppressive Therapy Iglesias-Escudero, María Segundo, David San Merino-Fernandez, David Mora-Cuesta, Victor M. Lamadrid, Patricia Alonso-Peña, Marta Raso, Sandra Iturbe, David Fernandez-Rozas, Sonia Cifrian, Jose López-Hoyos, Marcos Front Immunol Immunology Lung transplantation remains as a primary treatment for end-stage lung diseases. Although remarkable improvement has been achieved due to the immunosuppressive protocols, long-term survival for lung transplant recipients (LTR) is still limited. In the last few decades, an increasing interest has grown in the study of dysregulation of immune mechanisms underlying allograft failure. In this regard, myeloid-derived suppressor cells (MDSCs) could play an important role in the promotion of graft tolerance due to their immune regulatory function. Here, we describe for the first time circulating subsets MDSCs from LTR at several time points and we evaluate the relationship of MDSCs with sort-term lung transplant outcomes. Although no effect of MDSCs subsets on short-term clinical events was observed, our results determine that Mo-MDSCs frequencies are increased after acute cellular rejection (ACR), suggesting a possible role for Mo-MDSCs in the development of chronic lung allograft dysfunction (CLAD). Therefore, whether MDSCs subsets play a role as biomarkers of chronic rejection remains unknown and requires further investigations. Also, the effects of the different immunosuppressive treatments on these subpopulations remain under research and further studies are needed to establish to what extend MDSCs immune modulation could be responsible for allograft acceptance. Frontiers Media S.A. 2022-01-10 /pmc/articles/PMC8848105/ /pubmed/35185863 http://dx.doi.org/10.3389/fimmu.2021.788851 Text en Copyright © 2022 Iglesias-Escudero, Segundo, Merino-Fernandez, Mora-Cuesta, Lamadrid, Alonso-Peña, Raso, Iturbe, Fernandez-Rozas, Cifrian and López-Hoyos https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Iglesias-Escudero, María Segundo, David San Merino-Fernandez, David Mora-Cuesta, Victor M. Lamadrid, Patricia Alonso-Peña, Marta Raso, Sandra Iturbe, David Fernandez-Rozas, Sonia Cifrian, Jose López-Hoyos, Marcos Myeloid-Derived Suppressor Cells Are Increased in Lung Transplant Recipients and Regulated by Immunosuppressive Therapy |
title | Myeloid-Derived Suppressor Cells Are Increased in Lung Transplant Recipients and Regulated by Immunosuppressive Therapy |
title_full | Myeloid-Derived Suppressor Cells Are Increased in Lung Transplant Recipients and Regulated by Immunosuppressive Therapy |
title_fullStr | Myeloid-Derived Suppressor Cells Are Increased in Lung Transplant Recipients and Regulated by Immunosuppressive Therapy |
title_full_unstemmed | Myeloid-Derived Suppressor Cells Are Increased in Lung Transplant Recipients and Regulated by Immunosuppressive Therapy |
title_short | Myeloid-Derived Suppressor Cells Are Increased in Lung Transplant Recipients and Regulated by Immunosuppressive Therapy |
title_sort | myeloid-derived suppressor cells are increased in lung transplant recipients and regulated by immunosuppressive therapy |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8848105/ https://www.ncbi.nlm.nih.gov/pubmed/35185863 http://dx.doi.org/10.3389/fimmu.2021.788851 |
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