Cargando…
Implementation of a pathological diagnosis and treatment pathway may improve the molecular detection of lung cancer
BACKGROUND: The 2018 Guideline from the College of American Pathologists (CAP), the International Association for the Study of Lung Cancer (IASLC), and the Association for Molecular Pathology (AMP) established a benchmark turnaround time (TAT), according to which the results should be available to t...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8848391/ https://www.ncbi.nlm.nih.gov/pubmed/35282093 http://dx.doi.org/10.21037/atm-21-6230 |
_version_ | 1784652239546089472 |
---|---|
author | Shi, Chao Wei, Bing Liu, Xiaohui Meng, Lin Zhao, Chengzhi Chang, Yuxi Sun, Rui Zhang, Zhongxian Yu, Yang Ma, Jie |
author_facet | Shi, Chao Wei, Bing Liu, Xiaohui Meng, Lin Zhao, Chengzhi Chang, Yuxi Sun, Rui Zhang, Zhongxian Yu, Yang Ma, Jie |
author_sort | Shi, Chao |
collection | PubMed |
description | BACKGROUND: The 2018 Guideline from the College of American Pathologists (CAP), the International Association for the Study of Lung Cancer (IASLC), and the Association for Molecular Pathology (AMP) established a benchmark turnaround time (TAT), according to which the results should be available to the treating oncologist within 10 working days. This article focused on the application process of a new protocol for pathological diagnosis and gene testing pathway and a sample collector. We want to solve the problem that there are not enough puncture samples for gene testing, and the benchmark turnaround time of gene detection was long in clinic. METHODS: In this study, we established and validated a new protocol for a pathological diagnosis and treatment pathway that was tested in the Henan Cancer Hospital, China. The “Biology collector (BIOCO)” tool was designed by our team, was made of polyvinyl chloride (PVC) material (patent application number is 201820902335.6). It consisted of two round magnets on the collector that can be adsorbed on the microtome blade holder, thus making it to move arbitrarily. It collected specimens that were discarded when the wax block was trimmed. We analyzed the TAT, testing accuracy and anti-pollution of new protocol based on BIOCO, compared with the conventional process based on the Routine Collection (ROUCO). RESULTS: The new pathway adopts a parallel approach to conventional pathology and molecular pathology, which significantly shortens the TAT to 4–6 days. The use of the BIOCO tool can effectively save pathological samples, avoid cross-contamination, and reduce the time delay caused by re-sampling. Most importantly, its accuracy and effectiveness are consistent with conventional collection methods. CONCLUSIONS: The new diagnosis and treatment pathway based on the BIOCO collector can be used as a practical approach for the molecular diagnostic platform of the hospital pathology department. |
format | Online Article Text |
id | pubmed-8848391 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-88483912022-03-10 Implementation of a pathological diagnosis and treatment pathway may improve the molecular detection of lung cancer Shi, Chao Wei, Bing Liu, Xiaohui Meng, Lin Zhao, Chengzhi Chang, Yuxi Sun, Rui Zhang, Zhongxian Yu, Yang Ma, Jie Ann Transl Med Original Article BACKGROUND: The 2018 Guideline from the College of American Pathologists (CAP), the International Association for the Study of Lung Cancer (IASLC), and the Association for Molecular Pathology (AMP) established a benchmark turnaround time (TAT), according to which the results should be available to the treating oncologist within 10 working days. This article focused on the application process of a new protocol for pathological diagnosis and gene testing pathway and a sample collector. We want to solve the problem that there are not enough puncture samples for gene testing, and the benchmark turnaround time of gene detection was long in clinic. METHODS: In this study, we established and validated a new protocol for a pathological diagnosis and treatment pathway that was tested in the Henan Cancer Hospital, China. The “Biology collector (BIOCO)” tool was designed by our team, was made of polyvinyl chloride (PVC) material (patent application number is 201820902335.6). It consisted of two round magnets on the collector that can be adsorbed on the microtome blade holder, thus making it to move arbitrarily. It collected specimens that were discarded when the wax block was trimmed. We analyzed the TAT, testing accuracy and anti-pollution of new protocol based on BIOCO, compared with the conventional process based on the Routine Collection (ROUCO). RESULTS: The new pathway adopts a parallel approach to conventional pathology and molecular pathology, which significantly shortens the TAT to 4–6 days. The use of the BIOCO tool can effectively save pathological samples, avoid cross-contamination, and reduce the time delay caused by re-sampling. Most importantly, its accuracy and effectiveness are consistent with conventional collection methods. CONCLUSIONS: The new diagnosis and treatment pathway based on the BIOCO collector can be used as a practical approach for the molecular diagnostic platform of the hospital pathology department. AME Publishing Company 2022-01 /pmc/articles/PMC8848391/ /pubmed/35282093 http://dx.doi.org/10.21037/atm-21-6230 Text en 2022 Annals of Translational Medicine. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Original Article Shi, Chao Wei, Bing Liu, Xiaohui Meng, Lin Zhao, Chengzhi Chang, Yuxi Sun, Rui Zhang, Zhongxian Yu, Yang Ma, Jie Implementation of a pathological diagnosis and treatment pathway may improve the molecular detection of lung cancer |
title | Implementation of a pathological diagnosis and treatment pathway may improve the molecular detection of lung cancer |
title_full | Implementation of a pathological diagnosis and treatment pathway may improve the molecular detection of lung cancer |
title_fullStr | Implementation of a pathological diagnosis and treatment pathway may improve the molecular detection of lung cancer |
title_full_unstemmed | Implementation of a pathological diagnosis and treatment pathway may improve the molecular detection of lung cancer |
title_short | Implementation of a pathological diagnosis and treatment pathway may improve the molecular detection of lung cancer |
title_sort | implementation of a pathological diagnosis and treatment pathway may improve the molecular detection of lung cancer |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8848391/ https://www.ncbi.nlm.nih.gov/pubmed/35282093 http://dx.doi.org/10.21037/atm-21-6230 |
work_keys_str_mv | AT shichao implementationofapathologicaldiagnosisandtreatmentpathwaymayimprovethemoleculardetectionoflungcancer AT weibing implementationofapathologicaldiagnosisandtreatmentpathwaymayimprovethemoleculardetectionoflungcancer AT liuxiaohui implementationofapathologicaldiagnosisandtreatmentpathwaymayimprovethemoleculardetectionoflungcancer AT menglin implementationofapathologicaldiagnosisandtreatmentpathwaymayimprovethemoleculardetectionoflungcancer AT zhaochengzhi implementationofapathologicaldiagnosisandtreatmentpathwaymayimprovethemoleculardetectionoflungcancer AT changyuxi implementationofapathologicaldiagnosisandtreatmentpathwaymayimprovethemoleculardetectionoflungcancer AT sunrui implementationofapathologicaldiagnosisandtreatmentpathwaymayimprovethemoleculardetectionoflungcancer AT zhangzhongxian implementationofapathologicaldiagnosisandtreatmentpathwaymayimprovethemoleculardetectionoflungcancer AT yuyang implementationofapathologicaldiagnosisandtreatmentpathwaymayimprovethemoleculardetectionoflungcancer AT majie implementationofapathologicaldiagnosisandtreatmentpathwaymayimprovethemoleculardetectionoflungcancer |